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A Saud, M, Ahmed Saud, N, A Hamad, M, Farhan Gar, L. (1400). Role of Salvia officinal's Silver Nanoparticles in Attenuation Renal Damage in Rabbits Exposed to Methotrexate. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2021.356313.1821
M A Saud; N Ahmed Saud; M A Hamad; L Farhan Gar. "Role of Salvia officinal's Silver Nanoparticles in Attenuation Renal Damage in Rabbits Exposed to Methotrexate". سامانه مدیریت نشریات علمی, , , 1400, -. doi: 10.22092/ari.2021.356313.1821
A Saud, M, Ahmed Saud, N, A Hamad, M, Farhan Gar, L. (1400). 'Role of Salvia officinal's Silver Nanoparticles in Attenuation Renal Damage in Rabbits Exposed to Methotrexate', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2021.356313.1821
A Saud, M, Ahmed Saud, N, A Hamad, M, Farhan Gar, L. Role of Salvia officinal's Silver Nanoparticles in Attenuation Renal Damage in Rabbits Exposed to Methotrexate. سامانه مدیریت نشریات علمی, 1400; (): -. doi: 10.22092/ari.2021.356313.1821

Role of Salvia officinal's Silver Nanoparticles in Attenuation Renal Damage in Rabbits Exposed to Methotrexate

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 29 مهر 1400  XML اصل مقاله (760.92 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356313.1821
نویسندگان
M A Saud email 1؛ N Ahmed Saud2؛ M A Hamad1؛ L Farhan Gar1
1Biotechnology an Environmental Center, University of Al-Fallujah
2Department of Biology, College of Education for Pure Sciences University of Anbar
چکیده
     Nanomaterials are now considered in a wide range of applications from various fields such as biotechnology and biomedicine. The aim of the present study was to investigate the protective role of Salvia officinal's silver nanoparticles (SOSNPs) as antioxidant on nephrotic damage induced by methotrexate (MTX) in adult rabbits. Green silver nanoparticles were synthesized using alcoholic extract of salvia officinal's leaves, and were characterized by UV-spectrophotometry and scanning electron microscope. The mixing of the plant extract of S. officinal's with silver nitrate solution lead to changing of the reaction mixture color to yellowish within one hour and to dark brown after 8 hours. For studying the protective role of SOSNP, twenty eight adult Wister albino rabbits divided in to four groups, they were treated intramuscularly (twice per week) for 45 days as follows; T1: Salvia officinal's (SO)(150mg /Kg/.B.W)  , T2: Salvia officinal's Silver nanoparticles(SOSNP) (150mg/Kg B.W); T3: Methotrexate (MTX)(0.25mg/kg/ B.W) and SOSNP (150mg/Kg/B.W); T4: MTX(0.25mg/Kg B.W).  Blood collected at 0, 15, 30 and 45 days using retro-orbital sinus and cardiac puncture technique, then the factors of serum include:  malondialdehyde, glutathione in serum, creatinine, and blood urea nitrogen and uric acid concentrations were measured. The results showed that MTX (group T4) caused a case of oxidative stress by significant decrease in GSH, MDA and increase in serum creatinine, urea and uric acid concentrations. On the other hand, the protective role of SO and SOSNPs given concurrently with MTX was clarified in groups T2and T3 ,where there was alleviation of renal damage through correction of the previous mentioned parameters and  correction of antioxidant status. On conclusion, the current study documented the antioxidant activity and renal protective effects of SOSNPs against damaging effects of methotrexate in rabbits.
کلیدواژه‌ها
Salvia officinal's؛ silver nanoparticles؛ methotrexate؛ renal functions
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