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Aal-Aaboda, Munaf, Abu Raghif, A. R, Hadi, N. R. (1400). Renoprotective Potential of the Ultra-Pure Lipopolysaccharide from Rhodobacter Sphaeroides on Acutely Injured Kidneys in an Animal Model. سامانه مدیریت نشریات علمی, 76(6), 1755-1764. doi: 10.22092/ari.2021.356202.1803
Munaf Aal-Aaboda; A. R Abu Raghif; N. R Hadi. "Renoprotective Potential of the Ultra-Pure Lipopolysaccharide from Rhodobacter Sphaeroides on Acutely Injured Kidneys in an Animal Model". سامانه مدیریت نشریات علمی, 76, 6, 1400, 1755-1764. doi: 10.22092/ari.2021.356202.1803
Aal-Aaboda, Munaf, Abu Raghif, A. R, Hadi, N. R. (1400). 'Renoprotective Potential of the Ultra-Pure Lipopolysaccharide from Rhodobacter Sphaeroides on Acutely Injured Kidneys in an Animal Model', سامانه مدیریت نشریات علمی, 76(6), pp. 1755-1764. doi: 10.22092/ari.2021.356202.1803
Aal-Aaboda, Munaf, Abu Raghif, A. R, Hadi, N. R. Renoprotective Potential of the Ultra-Pure Lipopolysaccharide from Rhodobacter Sphaeroides on Acutely Injured Kidneys in an Animal Model. سامانه مدیریت نشریات علمی, 1400; 76(6): 1755-1764. doi: 10.22092/ari.2021.356202.1803

Renoprotective Potential of the Ultra-Pure Lipopolysaccharide from Rhodobacter Sphaeroides on Acutely Injured Kidneys in an Animal Model

Archives of Razi Institute
مقاله 21، دوره 76، شماره 6، بهمن و اسفند 2021، صفحه 1755-1764    اصل مقاله (663.92 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356202.1803
نویسندگان
Munaf Aal-Aaboda* 1؛ A. R Abu Raghif2؛ N. R Hadi3
1Department of Pharmacology, Faculty of Pharmacy, University of Misan
2Department of Pharmacology, Faculty of Medicine, Al-Nahrain University, Iraq
3Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Iraq
چکیده
One of the main causes of acute kidney injury is ischemic reperfusion injury (IRI). Inflammatory response, apoptotic damages, and oxidative stress-related injuries are all involved in the pathogenesis of IRI. Toll-like receptors (TLR) are strongly associated with IRIs, especially TLR4, which is markedly induced in response to IRI. Accordingly, the current study aimed to investigate the potential renoprotective effect of ultrapure lipopolysaccharide from Rhodobacter sphaeroides (ULPS-RS) at two doses in an animal model of bilateral IRI. A total of 30 adult male rats were divided randomly into five equal groups of control (laparotomy plus bilateral renal IRI), vehicle (same as the control group, but pretreated with the vehicle), sham (laparotomy only), ULPS-RS (same as the control group, but pretreated with 0.1 mg/kg of ULPS-RS), and ULPS-RSH (same as the control group, but pretreated with 0.2 mg/kg of ULPS-RS). Subsequent to 30 min of ischemia and 2 h of reperfusion, serum samples were collected for measuring urea, creatinine, and neutrophil gelatinase-associated lipocalin. Afterward, tissue samples were obtained from all animals to measure inflammatory mediators (interleukin 6, interleukin 1β, and tumor necrosis factor α), oxidative stress marker (8-isoprostane), apoptosis mediators (B cell lymphoma 2 [Bcl2]), and Bcl2-associated X protein (Bax). In the control group, all of the measured parameters were significantly elevated in response to IRI, except for Bcl2, which decreased significantly. On the other hand, exactly opposite effects were observed in the ULPS-RS treated groups indicating the nephroprotective effect of this compound against IRI at both tested doses. The findings reveal for the first time that ULPS-RS has the therapeutic potential of attenuating the renal dysfunction induced by IRI.
کلیدواژه‌ها
Bax؛ Bcl2؛ F2-isoprostane؛ IL-1β؛ IL6؛ Ischemic reperfusion injury؛ NGAL؛ pure TLR4 antagonist؛ TNFα
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