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| تعداد دریافت فایل اصل مقاله | 11,022,619 |
Enzymatic Effective of Alcoholic and Aqueous Extract of Salvia officnalis in Mice Poisoned with CCl4 | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 22 مهر 1400 اصل مقاله (676.36 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.356239.1812 | ||
| نویسندگان | ||
R Kadhim  ؛ N. H Ali؛ D Aziz Ibrahim
| ||
| Department of Chemical, College of Science, Tikrit University, Tikrit, Iraq | ||
| چکیده | ||
| Salvia officnalis extracts showed antioxidant,anti-inflammatory and antibacterial activity, and due to the use of medicinal herb as an alternative to chemical drugs to reduce damage of hepatocyte, in this study, enzymatic changes after treated of aqueous and alcoholic extract of Salvia officnalis in mice poisoned with carbon tetrachloride were evaluated.40adult male mice divided into 8 groups that included 6 experimental and negative and positive control groups, which were exposed to CCl4 at a concentration of 2.3 mg / kg. The active compounds in the alcoholic and aqueous extracts of S. officinalis using by HPLC and then mice were givenS. Officinalis extract orally 100, 200 and 300mg / kg for six days. The enzymes (GST, ALP, ALT, AST and MDA) were determined in serum. The result of the study showed that enzyme activity had significant decreased in the group treated with S. officinalis extract and the concentration 300mg / kg has the most effectiveness. Also, showed that the alcoholic extract has a higher effect than the aqueous extract that may be because the alcoholic extract contains a greater amount of active compounds.The improving effects of S. officinalis can be attributed to the bioactive components as antioxidant properties that inhibit the damaging effects of free radicals, chemical drugs and tissue damage. | ||
| کلیدواژه‌ها | ||
| Salvia officnalis؛ enzymatic effective؛ alcoholicextract؛ aqueous extract؛ CCl4 | ||
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آمار تعداد مشاهده مقاله: 5 تعداد دریافت فایل اصل مقاله: 2 |
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