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Mohammed, W. H, Soud, S. A, Hameed, A. H, Hussein, N. N. (1400). Assessment of the Cytotoxic Activity of Alcoholic Extract of Eucalyptus camaldulensis on Breast Cancer Cell Line. سامانه مدیریت نشریات علمی, 76(5), 1307-1314. doi: 10.22092/ari.2021.356104.1778
W. H Mohammed; S. A Soud; A. H Hameed; N. N Hussein. "Assessment of the Cytotoxic Activity of Alcoholic Extract of Eucalyptus camaldulensis on Breast Cancer Cell Line". سامانه مدیریت نشریات علمی, 76, 5, 1400, 1307-1314. doi: 10.22092/ari.2021.356104.1778
Mohammed, W. H, Soud, S. A, Hameed, A. H, Hussein, N. N. (1400). 'Assessment of the Cytotoxic Activity of Alcoholic Extract of Eucalyptus camaldulensis on Breast Cancer Cell Line', سامانه مدیریت نشریات علمی, 76(5), pp. 1307-1314. doi: 10.22092/ari.2021.356104.1778
Mohammed, W. H, Soud, S. A, Hameed, A. H, Hussein, N. N. Assessment of the Cytotoxic Activity of Alcoholic Extract of Eucalyptus camaldulensis on Breast Cancer Cell Line. سامانه مدیریت نشریات علمی, 1400; 76(5): 1307-1314. doi: 10.22092/ari.2021.356104.1778

Assessment of the Cytotoxic Activity of Alcoholic Extract of Eucalyptus camaldulensis on Breast Cancer Cell Line

Archives of Razi Institute
مقاله 19، دوره 76، شماره 5، بهمن و اسفند 2021، صفحه 1307-1314    اصل مقاله (489.35 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356104.1778
نویسندگان
W. H Mohammed* ؛ S. A Soud؛ A. H Hameed؛ N. N Hussein
Division of Biotechnology, Department of Applied Sciences, University of Technology, Baghdad, Iraq
چکیده
The spread of different types of cancer has been on a rise in the recent century. The use of chemical medications develops drug resistance and causes serious side effects. Eucalyptus camaldulensis (E. camaldulensis) is one of the most famous herbal remedies considered owing to its anti-inflammatory effect and boosting the intimate immune system; moreover, it has demonstrated some anti-proliferative effects on cancerous cell lines. The current study assessed the cytotoxic activity of alcoholic extract of Eucalyptus camaldulensis (E. camaldulensis) at different concentrations of 6.125, 12.5, 25, 50, and 100 µg/mL on breast cancer cell line MCF-7. The 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS)) analyses were employed to study the antioxidant efficiency of ethanolic extract of Eucalyptus camaldulensis. The results of Fourier transmission infra-red analysis and Phytochemical screening pointed to the presence of many active compounds in this extract, such as Tannins, Saponins, Phenolic compounds, Reducing sugar, Terpenoids, Steroids, Glucosides, Alkaloids, and Flavonoids. Furthermore, the results demonstrated that this extract significantly inhibited the growth of the MCF-7 cell line in a concentration-dependent manner, as compared to the control, and the cytotoxic activity of this extract elevated with an increase in the concentration. The results pointed out that E. camaldulensis can be considered a particularly valuable source of effective anti-proliferative and cytotoxic agents. The experimental findings demonstrated that E. camaldulensis extract possessed significant antioxidant efficiency and anti-proliferative effects on cancerous cell lines.
کلیدواژه‌ها
Antioxidant؛ Anti-proliferative؛ Breast cancer؛ Crud extract؛ Ethanol
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مراجع
  1. Silva J, Abebe W, Sousa SM, Duarte VG, Machado MI, Matos FJ. Analgesic and anti-inflammatory effects of essential oils of Eucalyptus. J Ethnopharmacol. 2003;89(2-3):277-83.
  2. Herzi N, Bouajila J, Camy S, Cazaux S, Romdhane M, Condoret JS. Comparison between supercritical CO2 extraction and hydrodistillation for two species of eucalyptus: yield, chemical composition, and antioxidant activity. J Food Sci. 2013;78(5):C667-72.
  3. Huang HC, Ho YC, Lim JM, Chang TY, Ho CL, Chang TM. Investigation of the Anti-Melanogenic and Antioxidant Characteristics of Eucalyptus camaldulensis Flower Essential Oil and Determination of Its Chemical Composition. Int J Mol Sci. 2015;16(5):10470-90.
  4. Doll-Boscardin PM, Sartoratto A, Sales Maia BH, Padilha de Paula J, Nakashima T, Farago PV, et al. In Vitro Cytotoxic Potential of Essential Oils of Eucalyptus benthamii and Its Related Terpenes on Tumor Cell Lines. Evid Based Complement Alternat Med. 2012;2012:342652.
  5. Garg V, Paliwal S. Anticonvulsant activity of ethanolic extract of Cynodon dactylon. Der Pharmacia Sinica. 2011;2:86-90.
  6. Venkateshwar C, GangadharRao S, editors. Preliminary Phytochemical Studies of Medicinal Plant Drug: Withania Somnifera Linn. 2014.
  7. Dillard CJ, German JB. Phytochemicals: nutraceuticals and human health. Sci Food Agric. 2000;80(12):1744-56.
  8. Deshmukh VN, DM S. Ethno pharmacological Review of Traditional Activity Int J Pharmtech Res. 2011;3(1):298-308.
  9. A.R A, Chughtai MI, Ashraf M, Mahmood K, Rizwan M, Akhtar M, et al. Comparison for physico-mechanical properties of farm-grown Eucalyptus camaldulensis Dehn. with conventional timbers. Pak J Bot. 2012;44:2067-70.
  10. Musa D, Eb O, Nwodo O. Phytochemical, Antibacterial and Toxicity Studies of The Aqueous Extract Of Euclayptus camaldulensis Dehnh. Asian J Plant Sci. 2011;1:1-10.
  11. Sultana S, Khan M, Ahmad M, Zafar M. Indigenous Knowledge of Folk Herbal Medicines by the Women of District Chakwal, Pakistan. Ethnobot leafl. 2006;10:243-53.
  12. Barra A, Coroneo V, Dessi S, Cabras P, Angioni A. Chemical Variability, Antifungal and Antioxidant Activity of Eucalyptus camaldulensis Essential Oil from Sardinia. Nat Prod Commun. 2010;5(2):329-35.
  13. El-Ghorab AH, El-Massry KF, Marx F, Fadel HM. Antioxidant activity of Egyptian Eucalyptus camaldulensis var. brevirostris leaf extracts. Nahrung. 2003;47(1):41-5.
  14. Ashraf, Sarfraz R, Anwar F, Shahid S, Alkharfy K. Chemical composition and biological activities of leaves of Ziziphus mauritiana L. native to Pakistan. Pak J Bot. 2015;47:367-76.
  15. Bibi G, Haq I, Ullah N, Mannan A, Mirza B. Antitumor, cytotoxic and antioxidant potential of Aster thomsonii extracts. Afr J Pharmacy Pharmacol. 2011;5:252-8.
  16. Barrett-Lee PJ, Dixon JM, Farrell C, Jones A, Leonard R, Murray N, et al. Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk. Ann Oncol. 2009;20(5):816-27.
Akin-Osanaiye BC, Agbaji AS, Dakare MA. Antimicrobial activity of oils and extracts of Cymbopogon citratus (Lemon grass), Eucalyptus citriodora and Eucalyptus camaldulensis. Med Sci. 2007;7(4):694-7.

18.          Akinnola O, Adeniyi B. The Antibacterial Activity of Leaf Extracts of Eucalyptus camaldulensis (Myrtaceae). J Appl Sci Res. 2008;4.
  • Akinnola O, Adeniyi B. The Antibacterial Activity of Leaf Extracts of Eucalyptus camaldulensis (Myrtaceae). J Appl Sci Res. 2008;4.
  • Nagpal N, Shah G, Arora N M, Shri R, Arya Y. Phytochemical and pharmacological aspects of Eucalyptus genus. Int J Pharm Sci. 2010;1(12):28-36.
  • Miliauskas G, Venskutonis PR, van Beek TA. Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem. 2004;85(2):231-7.
  • Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Rad Biol Med. 1999;26(9):1231-7.
  • Al-Shammari AM, Alshami MA, Umran MA, Almukhtar AA, Yaseen NY, Raad K, et al. Establishment and characterization of a receptor-negative, hormone-nonresponsive breast cancer cell line from an Iraqi patient. Breast Cancer (Dove Med Press). 2015;7:223-30.
  • Al-Shammari AM, Salman MI, Saihood YD, Yaseen NY, Raed K, Shaker HK, et al. In Vitro Synergistic Enhancement of Newcastle Disease Virus to 5-Fluorouracil Cytotoxicity against Tumor Cells. Biomedicines. 2016;4(1).
  • Adorjan B, Buchbauer G. Biological properties of essential oils: an updated review. Flavour Fragr J. 2010;25(6):407-26.
  • Ghassan Mohammad S, Nehia Nima H, Thorria Raddam M, Hussain Abood A. Phenolic Content, Antioxidant, Antimicrobial and Cytotoxic Activities of Ethanolic Extract of Salix alba. Flavour Fragr J. 2013;9(1).
  • Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006;71(10):1397-421.
  • Salomons GS, Smets LA, Verwijs-Janssen M, Hart AA, Haarman EG, Kaspers GJ, et al. Bcl-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome. Leukemia. 1999;13(10):1574-80.
  • Nasser M, Damaj R, Merah O, Hijazi A, Trabolsi C, Wehbe N, et al. Potency of Combining Eucalyptus camaldulensis subsp. camaldulensis with Low-Dose Cisplatin in A549 Human Lung Adenocarcinomas and MCF-7 Breast Adenocarcinoma. Medicines . 2020;7(8).
  • Sun Q, Heilmann J, Konig B. Natural phenolic metabolites with anti-angiogenic properties - a review from the chemical point of view. Beilstein J Org Chem. 2015;11:249-64.
  • Meshkani N, Ranjbar M, editors. Study of cytotoxic effects of Ethanolic extract of Eucalyptus camaldulensis leaf on the cells k562 of human chronic Myelogenous leukemia (CML) under in Vitro conditions. Bull Env Pharmacol Life Sci. 2014; 3: 186-190.
    1. Huang D, Ou B, Prior RL. The chemistry behind antioxidant capacity assays. J Agric Food Chem. 2005;53(6):1841-56.
    2. Prior RL, Cao G. In vivo total antioxidant capacity: comparison of different analytical methods1. Free Rad Biol Med. 1999;27(11):1173-81.
    3. Buenger J, Ackermann H, Jentzsch A, Mehling A, Pfitzner I, Reiffen KA, et al. An interlaboratory comparison of methods used to assess antioxidant potentials. Int J Cosmet Sci. 2006;28(2):135-46.
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