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Jawad, M. A, Kadhim, A. J, Hasan, S. Y. (1400). Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice. سامانه مدیریت نشریات علمی, 76(5), 1561-1564. doi: 10.22092/ari.2021.356080.1773
M. A Jawad; A. J Kadhim; S. Y Hasan. "Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice". سامانه مدیریت نشریات علمی, 76, 5, 1400, 1561-1564. doi: 10.22092/ari.2021.356080.1773
Jawad, M. A, Kadhim, A. J, Hasan, S. Y. (1400). 'Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice', سامانه مدیریت نشریات علمی, 76(5), pp. 1561-1564. doi: 10.22092/ari.2021.356080.1773
Jawad, M. A, Kadhim, A. J, Hasan, S. Y. Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice. سامانه مدیریت نشریات علمی, 1400; 76(5): 1561-1564. doi: 10.22092/ari.2021.356080.1773

Histological Study of the Effect of Aqueous Extract of the Beetle Cocoon on Liver Tissue of Male Mice

Archives of Razi Institute
مقاله 47، دوره 76، شماره 5، بهمن و اسفند 2021، صفحه 1561-1564    اصل مقاله (449.64 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22092/ari.2021.356080.1773
نویسندگان
M. A Jawad* 1؛ A. J Kadhim1؛ S. Y Hasan2
1Al-Nisour University College, Baghdad, Iraq
2National University for Science And Technology, Nasiriyah, Iraq
چکیده
Traditional medicine has been long used to prevent and/or treat diseases worldwide based on a wealth of experiences, principles, and beliefs in different cultures. Among the extracts used in traditional medicine, we can refer to the aqueous beetle cocoon extract of Larinus maculates popularly known as Tihan in Iraq. To determine the histological effect of this extract on mice liver tissue, the animals were assigned to four groups (n=5) treated with (150,200,400) mg/kg of Cocoon aqueous extract of Larinus maculates for 14 days, respectively. Histology and immunohistochemistry test was performed to evaluate changes in liver tissue and tumor necrosis factor alpha (TNF-α) levels.The results showed various pathological dose-depended changes in the liver tissue, including infiltrations, congestion, and vacuolation, along with some dead cells; moreover, necrotic hepatocytes were observed in the liver of highly concentrated treatment group (400 mg kg-1). In addition, the TNF-α level in the liver tissue was elevated by the increased concentration of the extract. The immunohistochemistry result of positive reaction to TNF-α revealed high reaction in the liver tissue of mice treated with 200 mg kg-1 and 400 mg kg-1, as compared to the control group. Furthermore, as evidenced by the obtained results, changes in hepatocytes and the severity of pathological changes in the liver depends on the concentration of the extract of Larinus maculates.
کلیدواژه‌ها
Larinus maculates؛ Histological changes؛ Liver؛ Male mice
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مراجع
  1. Cohen PA, Ernst E. Safety of herbal supplements: a guide for cardiologists. Cardiovasc Ther. 2010;28(4):246-53.
  2. Evans M, Shaw A, Thompson EA, Falk S, Turton P, Thompson T, et al. Decisions to use complementary and alternative medicine (CAM) by male cancer patients: information-seeking roles and types of evidence used. BMC Complement Altern Med. 2007;7:25.
  3. Hamedi A, Farjadian S, Karami MR. Immunomodulatory properties of Trehala manna decoction and its isolated carbohydrate macromolecules. J Ethnopharmacol. 2015;162:121-6.
  4. Z. T. Alasady, Alsaheb HSA, Jwad MS. The effect of Larinus maculates F. cocoon aqueous extract in some Immunological Aspects of male albino mice. Jpur Applied Sci. 2017:153-9.
  5. Tawfeeq EN. Study the effect of hot aqueous extract of beetle cocoon Larinus maculatus F. on some physiological parameters in male albino mice. Pharm Biological Sci. 2018;13(1): 61-4.
  1. Im AR, Yang WK, Park YC, Kim SH, Chae S. Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease. Nutrients. 2018;10(6).
  2. Jasso-Villagomez EI, Garcia-Lorenzana M, Almanza-Perez JC, Fortis-Barrera MA, Blancas-Flores G, Roman-Ramos R, et al. Beetle (Ulomoides dermestoides) fat improves diabetes: effect on liver and pancreatic architecture and on PPARgamma expression. Braz J Med Biol Res. 2018;51(6):7238.
  3. Anbarasu C, Rajkapoor B, Bhat KS, Giridharan J, Amuthan AA, Satish K. Protective effect of Pisonia aculeata on thioacetamide induced hepatotoxicity in rats. Asian Pac J Trop Biomed.2012;2(7):511-5.
  4. DeFoliart GR. The Human Use of Insects as Food Resources: A bibliographic account in progress: Central and Eastern Africa overview; 2002.
  5. Biancotti J, Kumar S, de Vellis J, Drapeau V, Després J, Bouchard C, et al. Theory and Practice of Histological Techniques, Edinburgh: Churchill Livingstone. Cognitive Impairments of Sleep-Deprived Ovariectomized Female Rats by Voluntary Exercise. 1982;11(5):2615-28.
  6. Taylor CR, Rudbeck L. Immunohistochemical Staining Methodes. 6th ed. Denmark: DakoAnagilent Technologies Company; 2013.
  7. Amacher DE, Chalasani N. Drug-induced hepatic steatosis. Semin Liver Dis. 2014;34(2):205-14.
  8. Hussain ZK. Histological Study on the Effect of Ampiroxicam Drug on liver of Females Mice. Iraqi J Sci. 2015;56(1A):105-11.
  9. Kumar V, Abbas AK, Fausto N, Mitchell RN. Robbins Basic Pathology. China: Saunders Elsevier; 2007.
  10. Kumar V, Abbas AK, Aster JK. Robbins Basic Pathology. Canada: animperint of Elsevier Inc.; 2013.
  11. Semisch A, Ohle J, Witt B, Hartwig A. Cytotoxicity and genotoxicity of nano - and microparticulate copper oxide: role of solubility and intracellular bioavailability. Part Fibre Toxicol. 2014;11:10.
  12. Sawai H. Characterization of TNF-induced caspase-independent necroptosis. Leuk Res. 2014;38(6):706-13.
18.          Matsukawa A, Yoshimura T, Maeda T, Takahashi T, Ohkawara S, Yoshinaga M. Analysis of the cytokine network among tumor necrosis factor alpha, interleukin-1beta, interleukin-8, and interleukin-1 receptor antagonist in monosodium urate crystal-induced rabbit arthritis. Lab Invest. 1998;78(5):559-69.

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