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Zhernakova, N. I, Bunova, S. S, Agarkov, N. M, Lebedev, D. T, Aksenov, V. V. (1400). Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly. سامانه مدیریت نشریات علمی, 76(4), 1069-1076. doi: 10.22092/ari.2021.356047.1766
N. I Zhernakova; S. S Bunova; N. M Agarkov; D. T Lebedev; V. V Aksenov. "Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly". سامانه مدیریت نشریات علمی, 76, 4, 1400, 1069-1076. doi: 10.22092/ari.2021.356047.1766
Zhernakova, N. I, Bunova, S. S, Agarkov, N. M, Lebedev, D. T, Aksenov, V. V. (1400). 'Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly', سامانه مدیریت نشریات علمی, 76(4), pp. 1069-1076. doi: 10.22092/ari.2021.356047.1766
Zhernakova, N. I, Bunova, S. S, Agarkov, N. M, Lebedev, D. T, Aksenov, V. V. Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly. سامانه مدیریت نشریات علمی, 1400; 76(4): 1069-1076. doi: 10.22092/ari.2021.356047.1766

Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly

Archives of Razi Institute
مقاله 37، دوره 76، شماره 4، آذر و دی 2021، صفحه 1069-1076    اصل مقاله (395.82 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356047.1766
نویسندگان
N. I Zhernakova* 1؛ S. S Bunova1؛ N. M Agarkov1، 2؛ D. T Lebedev1؛ V. V Aksenov2
1FGAOU VO, Belgorod State National Research University, Belgorod, Russia
2FGBOU VO, South-West State University, Kursk, Russia
چکیده
Cardiovascular diseases are among the most common causes of disability and death in the world, and the number of patients with this category of diseases is increasing every year. This study aimed to investigate the role of vitamin D and the problems caused by its deficiency on the cardiovascular system. Level of D-(25[OH]D) in blood was studied by enzyme immunoassay in 95 elderly patients with myocardial infarction (MI) (the main group) and 92 elderly patients with no history of MI. The level of lipid metabolism as an indicator was determined using a KoneLab 300 auto-analyzer. Based on the results of this study, it was found that the elderly group without MI had the highest amount of D-(25[OH]D)(24.5±1.2), compared to the elderly group with MI (14.8±1.3). The rates of expressed deficiency, deficiency, and insufficiency in the group of elderly with MI were 53.6±5.1, 23.2±4.4, and 12.6±3.4%, respectively. This experiment has shown that D-(25[OH]D) is involved in lipid metabolism and reduces the accumulation of cholesterol by macrophages. The content of vitamin D in blood plasma was a prognostic predictor of MI, which improved MI in the elderly. Regardless of pathological changes, the deficit level of D-(25[OH]D) should be considered a laboratory predictor of MI in the elderly.
کلیدواژه‌ها
Lipid metabolism؛ Myocardial infarction؛ Old age Prognostic value؛ Vitamin D
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