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Wound Infection with Multi Drug Resistant Clostridium perfringens- A Case Study | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 04 مهر 1400 اصل مقاله (573.52 K) | ||
| نوع مقاله: Case Study | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.355985.1757 | ||
| نویسندگان | ||
R Khandia   1؛ N Puranik1؛ D Bhargava1؛ N Lodhi1؛ B Gautam1؛ K Dhama2
| ||
| 1Department of Biochemistry and Genetics, Barkatullah University, Bhopal 462026 MP, India | ||
| 2Division of Pathology, Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, UP, India | ||
| چکیده | ||
| Wound infections are a public health problem worldwide. However, progress has been made in improving surgical techniques and antibiotic treatment. Misuse / overuse of antibiotics to prevent and treat bacterial infections eventually leads to increased bacterial resistance with rising incidences of multi-drug resistant (MDR) bacterial strains. The wider dissemination of antibiotics, may ultimately result in ineffectiveness to antibiotic therapy and thereby complicating / graving the outcome of a patient. In the present study, a 60-year-old male patient having wound infection with MDR bacterium that ultimately required surgical amputation of the toe was investigated. For the confirmation of MDR bacterium, two culture media viz., Mcconkey Agar and Mueller Hinton Agar media were used. The sensitivity of the isolated strain for various antibiotics was tested using the disc diffusion method. The wound sample was found positive for Gram-positive bacterium that was identified as Clostridium perfringens. The bacterium was screened for 40 antibiotics and among all the antibiotics it was found sensitive for only Piperacillin/Tazobactam antibiotic combination. C. perfringens bacterium caused the gas gangrene in the infected wound part of the patient. Amputation of the gangrene affected foot part was done by surgery, and with good medical care the person recovered fast. To the best of our knowledge, this is the first ever report of MDR C. perfringens single isolate harbouring resistance against at least 40 antibiotics tested. More research is needed to develop really new and effective medicines that do not cross-react with antibiotics now in use and have robust activity against MDR organisms. | ||
| کلیدواژه‌ها | ||
| Multi drug resistance؛ wound؛ Gas gangrene؛ Clostridium perfringens | ||
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آمار تعداد مشاهده مقاله: 11 تعداد دریافت فایل اصل مقاله: 19 |
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