Influence of Microbiota in the Development of Breast Cancer

Saud Hussein, A; Ibraheem Salih, N; Hashim Saadoon, I

doi:10.22092/ari.2021.355961.1750

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	Influence of Microbiota in the Development of Breast Cancer
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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 30 شهریور 1400 اصل مقاله (548.54 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355961.1750
نویسندگان
A Saud Hussein ¹؛ N Ibraheem Salih²؛ I Hashim Saadoon²
¹Department of Biology, College of Science, Kirkuk University, Kirkuk, Iraq
²Department of Microbiology, College of Medicine, Tikrit University, Tikrit, Iraq
چکیده
Breast cancer is the most frequent cancer among women, it also causes the greatest number of cancer-related death among women all over the world. It approximately accounts for 15% of all cancer death. The human microbiota is the term applied to the universe of microbes that live in different habitats of living organisms' body not only in the gut, skin, vagina, and mouth, but also in the nose, conjunctiva, pharynx and urethra, among others. Increasing evidence is pointing to the role of microbiome in the occurrence and development of a variety of cancers. For example, intestinal microbiome imbalance is related to the occurrence of gastrointestinal tumors such as esophageal, gastric, colorectal, and gallbladder cancer. The aim of the present study was to identify the role of microbiota in the development of breast cancer. The present study was carried out in Kirkuk city from of 10^th September 2019 to 15^th of March 2020, the number of breast cancer women under study were 130 women. The control group who were matched to the breast cancer patients studied, included 20 women diagnosed as having benign breast lesions and whose ages were between 25-75 years old. Blood samples and breast tissue samples were taken from breast cancer and benign breast lesions patients. Blood samples were examined by immunological methods, enzyme linked immuno sorbent assay for detection interleukin-19 (IL-19), breast tissue samples were taken from breast cancer and benign breast lesions patients for isolation and identification of bacteria. The present study revealed that only 6 out of 30 (20%) of women with breast cancer revealed bacterial growth on culture, about 4 out of 6 (67%) of positive cultures among breast cancer cases was Escherichia coli while 2(33%) was Staphylococcus aureus, this relation was statistically significant, no one of women with benign breast lesion revealed bacterial growth, also difference between women with positive result of bacterial culture and those with negative result and stages of breast cancer was statistically non- significant. Half number of women with breast cancer and bacterial growth was within the age group 40-49 year (50 %). The present study showed the difference was statistically highly significant between women with breast cancer and with benign breast lesions according to residence. The study showed that mean level of IL-19 among breast cancer women was lower than that of benign breast lesion, this relation was statistically highly significant.
کلیدواژه‌ها
Breast Cancer؛ Microbiota؛ IL-19

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Influence of Microbiota in the Development of Breast Cancer