اخبار و اعلانات

 آمار

تعداد نشریات285
تعداد نشریات سازمان83
تعداد شماره‌ها3,115
تعداد مقالات34,682
تعداد مشاهده مقاله49,902,756
تعداد دریافت فایل اصل مقاله80,223,081
Saud Hussein, A, Ibraheem Salih, N, Hashim Saadoon, I. (1400). Effect of Microbiota in the Development of Breast Cancer. سامانه مدیریت نشریات علمی, 76(4), 761-768. doi: 10.22092/ari.2021.355961.1750
A Saud Hussein; N Ibraheem Salih; I Hashim Saadoon. "Effect of Microbiota in the Development of Breast Cancer". سامانه مدیریت نشریات علمی, 76, 4, 1400, 761-768. doi: 10.22092/ari.2021.355961.1750
Saud Hussein, A, Ibraheem Salih, N, Hashim Saadoon, I. (1400). 'Effect of Microbiota in the Development of Breast Cancer', سامانه مدیریت نشریات علمی, 76(4), pp. 761-768. doi: 10.22092/ari.2021.355961.1750
Saud Hussein, A, Ibraheem Salih, N, Hashim Saadoon, I. Effect of Microbiota in the Development of Breast Cancer. سامانه مدیریت نشریات علمی, 1400; 76(4): 761-768. doi: 10.22092/ari.2021.355961.1750

Effect of Microbiota in the Development of Breast Cancer

Archives of Razi Institute
مقاله 7، دوره 76، شماره 4، آذر و دی 2021، صفحه 761-768    اصل مقاله (460.42 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355961.1750
نویسندگان
A Saud Hussein* 1؛ N Ibraheem Salih2؛ I Hashim Saadoon2
1Department of Biology, College of Science, Kirkuk University, Kirkuk, Iraq
2Department of Microbiology, College of Medicine, Tikrit University, Tikrit, Iraq
چکیده
Breast cancer is the most frequent cancer among women and causes the greatest number of cancer-related death among women all over the world. It approximately accounts for 15% of all cancer death. The human microbiota is the term applied to the aggregate of microbes that live in different habitats of living organisms 'bodies, including the gut, skin, vagina, and mouth,  as well as nose, conjunctiva, pharynx, and urethra, among others. Increasing evidence is pointing to the role of the microbiome in the occurrence and development of a variety of cancers. Intestinal microbiome imbalance is related to the occurrence of gastrointestinal tumors, such as esophageal, gastric, colorectal, and gallbladder cancer. The present study aimed to identify the role of microbiota in the development of breast cancer. The women with breast cancer (n=130) in this study were in the age range of 25-75 years. The study was conducted in Kirkuk city of Iraq from September 10, 2019, to March 15, 2020. The control group included 20 women diagnosed with benign breast lesions in the age range 25-75 years, who matched the women in the patient group. Blood samples and breast tissue samples were taken from patients with breast cancer and benign breast lesions. Blood samples were examined through immunological methods, enzyme-linked immunosorbent assay (ELISA) was adopted for the detection of interleukin-19 (IL-19). Breast tissue samples were taken from breast cancer and benign breast lesions patients to isolate and identify bacteria. Based on the obtained results, only 6 out of 30 (20%) cultured breast tissue samples from women with breast cancer showed bacterial growth.  In total, 4 (67%) and 2(33%) of these 6 positive cultures were Escherichia coli was and Staphylococcus aureus, respectively, and this relation was statistically significant. However, no bacterial growth was observed on the cultured breast tissue samples taken from women with benign breast lesions. Moreover, the difference between women with a positive and negative result of bacterial culture and stages of breast cancer was statistically non-significant.  It is worth mentioning that 50 % of women with breast cancer and bacterial growth were within the age range of 40-49 year. The present study revealed that the difference between women with breast cancer and those with benign breast lesions was statistically highly significant according to the place of residence. In addition, the mean level of IL-19 among women with breast cancer was lower than that in women with benign breast lesions, and this relation was statistically highly significant.
کلیدواژه‌ها
Breast Cancer؛ IL-19؛ Microbiota
سایر فایل های مرتبط با مقاله
مراجع
  1. Breast cancer [Internet]. WHO. 2018. Available from: http://www.who.int/cancer/prevention/diagnosis-screening/breast-cancer/en/.
  2. S. B. Molecular Pathology of Breast Cancer. 1st ed. New York: Springer-Verlag; 2016.
  3. Caputi V, Giron MC. Microbiome-gut-brain axis and toll-like receptors in Parkinson’s disease. Int J Mol Sci. 2018;19(6):1689.
  4. Rea D, Coppola G, Palma G, Barbieri A, Luciano A, Del Prete P, et al. Microbiota effects on cancer: from risks to therapies. Oncotarget. 2018;9(25):17915.
  5. Selber-Hnatiw S, Rukundo B, Ahmadi M, Akoubi H, Al-Bizri H, Aliu AF, et al. Human gut microbiota: toward an ecology of disease. Front Microbiol. 2017;8:1265.
  6. Rajagopala SV, Vashee S, Oldfield LM, Suzuki Y, Venter JC, Telenti A, et al. The human microbiome and cancer. Cancer Prev Res. 2017;10(4):226-34.
  7. Chase D, Goulder A, Zenhausern F, Monk B, Herbst-Kralovetz M. The vaginal and gastrointestinal microbiomes in gynecologic cancers: a review of applications in etiology, symptoms and treatment. Gynecol Oncol. 2015;138(1):190-200.
  8. Sabat R. IL-10 family of cytokines. Cytokine & growth factor reviews. 2010;21(5):315-24.
  9. Jordan WJ, Eskdale J, Boniotto M, Lennon GP, Peat J, Campbell JD, et al. Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10. Eur J Immunol. 2005;35(5):1576-82.
  10. Liao Y-C, Liang W-G, Chen F-W, Hsu J-H, Yang J-J, Chang M-S. IL-19 induces production of IL-6 and TNF-α and results in cell apoptosis through TNF-α. J Immunol. 2002;169(8):4288-97.
  11. Azuma Y-T, Matsuo Y, Nakajima H, Yancopoulos GD, Valenzuela DM, Murphy AJ, et al. Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection. J Pharmacol Sci. 2011;115(2):105-11.
  12. Cantó E, Garcia Planella E, Zamora-Atenza C, Nieto JC, Gordillo J, Ortiz MA, et al. Interleukin-19 impairment in active Crohn’s disease patients. PLoS One. 2014;9(4):e93910.
  13. Yeh C-H, Cheng B-C, Hsu C-C, Chen H-W, Wang J-J, Chang M-S, et al. Induced interleukin-19 contributes to cell-mediated immunosuppression in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. Ann Thorac Surg. 2011;92(4):1252-9.
  14. Xuan C, Shamonki JM, Chung A, DiNome ML, Chung M, Sieling PA, et al. Microbial dysbiosis is associated with human breast cancer. PloS one. 2014;9(1):e83744.
  15. Goedert JJ, Jones G, Hua X, Xu X, Yu G, Flores R, et al. Investigation of the association between the fecal microbiota and breast cancer in postmenopausal women: a population-based case-control pilot study. J Natl Cancer Inst. 2015;107(8).
  16. Luu TH, Michel C, Bard J-M, Dravet F, Nazih H, Bobin-Dubigeon C. Intestinal proportion of Blautia sp. is associated with clinical stage and histoprognostic grade in patients with early-stage breast cancer. Nutr Cancer. 2017;69(2):267-75.
  17. Urbaniak C, Gloor GB, Brackstone M, Scott L, Tangney M, Reid G. The microbiota of breast tissue and its association with breast cancer. Appl Environ Microbiol. 2016;82(16):5039-48.
  18. Hieken TJ, Chen J, Hoskin TL, Walther-Antonio M, Johnson S, Ramaker S, et al. The microbiome of aseptically collected human breast tissue in benign and malignant disease. Sci Rep. 2016;6(1):1-10.
  19. Koller VJ, Marian B, Stidl R, Nersesyan A, Winter H, Simić T, et al. Impact of lactic acid bacteria on oxidative DNA damage in human derived colon cells. Food Chem Toxicol. 2008;46(4):1221-9.
  20. Hummelen R, Fernandes AD, Macklaim JM, Dickson RJ, Changalucha J, Gloor GB, et al. Deep sequencing of the vaginal microbiota of women with HIV. PloS one. 2010;5(8):e12078.
  21. Wade WG. The oral microbiome in health and disease. Pharmacol Res. 2013;69(1):137-43.
  22. Wolfe AJ, Toh E, Shibata N, Rong R, Kenton K, FitzGerald M, et al. Evidence of uncultivated bacteria in the adult female bladder. J Clin Microbiol. 2012;50(4):1376-83.
  23. Goldsmith F, O’Sullivan A, Smilowitz JT, Freeman SL. Lactation and intestinal microbiota: how early diet shapes the infant gut. J Mammary Gland Biol Neoplasia. 2015;20(3):149-58.
  24. Thongaram T, Hoeflinger JL, Chow J, Miller MJ. Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli. J Dairy Sci. 2017;100(10):7825-33.
  25. Quong J, Eppenberger-Castori S, Moore D, Scott GK, Birrer MJ, Kueng W, et al. Age-dependent changes in breast cancer hormone receptors and oxidant stress markers. Breast Cancer Res Treat. 2002;76(3):221-36.
  26. AbdullahAbbas A, Saadoon IH. Relation of Epstein Barr virus with Interleukin-6 Level among Women with Breast Cancer in Ramadi City. Med-Leg Update. 2020;20(1):1393-8.
  1. Malvia S, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol. 2017;13(4):289-95.
  2. Meng S, Chen B, Yang J, Wang J, Zhu D, Meng Q, et al. Study of microbiomes in aseptically collected samples of human breast tissue using needle biopsy and the potential role of in situ tissue microbiomes for promoting malignancy. Front Oncol. 2018;8:318.
  3. Stewart T, Heppner G. Immunological enhancement of breast cancer. Parasitology. 1997;115(7):141-53.
  4. S SP. Serum cytokines levels of interleukin -8 and tumor necrosis factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q10, riboflavin and niacin. Basic Clin Pharmacol Toxicol 2007;100:387-91.
  5. Musselman DL, Miller AH, Porter MR, Manatunga A, Gao F, Penna S, et al. Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings. Am J Psychiatry. 2001;158(8):1252-7.
  6. Lyon DE, McCain NL, Walter J, Schubert C. Cytokine comparisons between women with breast cancer and women with a negative breast biopsy. Nurs Res. 2008;57(1):51.
  7. Mehdipour F, Malekzadeh M, Talei A, Ghaderi A. Decreased Serum Level of Interleukin-19 in Iranian Patients with Breast Cancer. Middle East J Cancer. 2015;6(4):203-9.
  8. Hsing C-H, Cheng H-C, Hsu Y-H, Chan C-H, Yeh C-H, Li C-F, et al. Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome. Clin Cancer Res. 2012;18(3):713-25.
  9. Chen Y-Y, Li C-F, Yeh C-H, Chang M-S, Hsing C-H. Interleukin-19 in breast cancer. Clin Dev Immunol. 2013;2013.
  10. Santulli P, Borghese B, Chouzenoux S, Streuli I, Borderie D, de Ziegler D, et al. Interleukin-19 and interleukin-22 serum levels are decreased in patients with ovarian endometrioma. Fertil Steril. 2013;99(1):219-26. e2.
  11. Santulli P, Borghese B, Chouzenoux S, Vaiman D, Borderie D, Streuli I, et al. Serum and peritoneal interleukin-33 levels are elevated in deeply infiltrating endometriosis. Hum Reprod. 2012;27(7):2001-9.
آمار
تعداد مشاهده مقاله: 3,679
تعداد دریافت فایل اصل مقاله: 3,881


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب