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Mohammed, A. S, Al-Janabi, A. A. (1400). Analytical Computation of Interleukin17A Activity in Breast Cancer Patients Using Bioinformatics Methods. سامانه مدیریت نشریات علمی, 76(4), 895-901. doi: 10.22092/ari.2021.355942.1743
A. S Mohammed; A. A Al-Janabi. "Analytical Computation of Interleukin17A Activity in Breast Cancer Patients Using Bioinformatics Methods". سامانه مدیریت نشریات علمی, 76, 4, 1400, 895-901. doi: 10.22092/ari.2021.355942.1743
Mohammed, A. S, Al-Janabi, A. A. (1400). 'Analytical Computation of Interleukin17A Activity in Breast Cancer Patients Using Bioinformatics Methods', سامانه مدیریت نشریات علمی, 76(4), pp. 895-901. doi: 10.22092/ari.2021.355942.1743
Mohammed, A. S, Al-Janabi, A. A. Analytical Computation of Interleukin17A Activity in Breast Cancer Patients Using Bioinformatics Methods. سامانه مدیریت نشریات علمی, 1400; 76(4): 895-901. doi: 10.22092/ari.2021.355942.1743

Analytical Computation of Interleukin17A Activity in Breast Cancer Patients Using Bioinformatics Methods

Archives of Razi Institute
مقاله 19، دوره 76، شماره 4، آذر و دی 2021، صفحه 895-901    اصل مقاله (415.77 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355942.1743
نویسندگان
A. S Mohammed* ؛ A. A Al-Janabi
Department of Applied Sciences, University of Technology, Baghdad, Iraq
چکیده
Interleukin-17A (IL-17A) is a member of the Interleukin-17 family, which belongs to the pro-inflammatory cystine-knot cytokines. Recent studies on the etiology of breast cancer have focused on the role of immunity and inflammation. The pro-inflammatory cytokines IL-17A can medicate cancer-related inflammation. The present study aimed to analyze the mutation in physicochemical properties and structure of the Interleukin-17Agenein developing breast cancer using bioinformatics methods. A total of 60 blood samples were obtained from Iraqi women aged 25 to 75 with breast cancer. Twenty blood samples were obtained from healthy women in the same age range as a control group. Deletion and missense mutations detected by BLAST in samples with breast cancer. The present study determined the physicochemical properties of IL-17A such as hydrophilic nature, alpha-helical and 3D structure. The results of this study indicated that IL-17Ais considered a marker for a patient with breast cancer. Also, mutations in the IL-17Agene affect the structure and physicochemical properties of the IL-17A protein complex.
کلیدواژه‌ها
Bioinformatics؛ Breast Cancer؛ IL-17A
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مراجع
  1. Aston KI. Genetic susceptibility to male infertility: news from genome-wide association studies. Andrology. 2014;2(3):315-21.
  2. Al-khafaji Z, Al-sheikhly A. Bioinformatics. Baghdad Iraq: University of Al-Nahrain Press; 2012.
  3. Hao L, Leng J, Xiao R, Kingsley T, Li X, Tu Z, et al. Bioinformatics analysis of the prognostic value of Tripartite Motif 28 in breast cancer. Oncol Lett. 2017;13(4):2670-8.
  4. Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, et al. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J. 2001;20(19):5332-41.
  5. Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity. 2004;21(4):467-76.
  6. Reis-Filho JS, Pusztai L. Gene expression profiling in breast cancer: classification, prognostication, and prediction. The Lancet. 2011;378(9805):1812-23.
  7. Li Q, Kang T, Tian X, Ma Y, Li M, Richards J, et al. Multimeric stability of human C-reactive protein in archived specimens. PLoS One. 2013;8(3):e58094.
  8. Koressaar T, Lepamets M, Kaplinski L, Raime K, Andreson R, Remm M. Primer3_masker: integrating masking of template sequence with primer design software. Bioinformatics. 2018;34(11):1937-8.
  9. Ye J, Coulouris G, Zaretskaya I, Cutcutache I, Rozen S, Madden TL. Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. BMC Bioinform. 2012;13:134.
  10. Dhary Kamel M, Mohammed A, Ibrahim A. Sequence and Structure Analysis of CRP of Lung and Breast Cancer Using Bioinformatics Tools and Techniques. Biosci Biotechnol Res Asia. 2018;15:163-74.
  11. Gasteiger E, Hoogland C, Gattiker A, Duvaud Se, Wilkins MR, Appel RD, et al. Protein Identification and Analysis Tools on the ExPASy Server. In: Walker JM, editor. The Proteomics Protocols Handbook. Totowa, NJ: Humana Press; 2005. p. 571-607.
  12. Biasini M, Bienert S, Waterhouse A, Arnold K, Studer G, Schmidt T, et al. SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information. Nucleic Acids Res. 2014;42(Web Server issue):W252-8.
  13. Venselaar H, Te Beek TA, Kuipers RK, Hekkelman ML, Vriend G. Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces. BMC Bioinform. 2010;11:548.
  14. Gamage DG, Gunaratne A, Periyannan GR, Russell TG. Applicability of Instability Index for In vitro Protein Stability Prediction. Protein Pept Lett. 2019;26(5):339-47.
  1. Tokuriki N, Tawfik DS. Stability effects of mutations and protein evolvability. Curr Opin Struct Biol. 2009;19(5):596-604.
  2. Kamimura K. Identification of molecular transition of hepatocellular carcinoma: a novel method to predict the initiation of metastasis. Stem Cell Investig. 2019;6:5.
  3. Zhao S, Liu J, Nanga P, Liu Y, Cicek AE, Knoblauch N, et al. Detailed modeling of positive selection improves detection of cancer driver genes. Nat Commun. 2019;10(1):3399.
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