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Effect of Anti-TNFα Therapy by Infliximab against Pancreatic Tissue Damage in Severe Acute Necrotizing Pancreatitis | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 شهریور 1400 اصل مقاله (900.78 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.355845.1726 | ||
| نویسندگان | ||
S A Alekhin  ؛ T I Firsova؛ D P Nazarenko؛ E N Bezhina؛ L V Druzhikin
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| Belgorod State University, Pobedy St., 85, Belgorod, 308015, Russia | ||
| چکیده | ||
| Nowadays, it is difficult to find a more complicated inflammatory disease of the abdominal organs in its pathogenesis than acute pancreatitis. Usage of antimediatory drugs and antimetabolites is the most promising direction in inflammatory pathological processes correction. The study of the possible uses of a new group of drugs – monoclonal antibodies to this trigger of inflammation- is also of great interest. Current study was aimed to study the effect of Infliximab on the lethality, volume and nature of the pancreatic lesion in severe necrotizing ductal pancreatic necrosis. The experiment was performed on 30 female Wistar rats of the same age weighing 200-250g. All manipulations were performed under general anesthesia by intraperitoneal injection of the zoletil at a dose of 60 mg/kg and chloral hydrate at a dose of 125 mg/kg. Model of severe acute necrotizing pancreatitis was performed by invented method with the injection of 0.5 ml of a buffer solution containing a bile acid salt - sodium taurocholate introductory. The animals were divided into following groups: Group A normal values (n = 6); Group B (n = 6), in a period of 24 h mortality study was conducted in acute destructive pancreatitis; Group C (n = 6), the group in which the simulation of acute severe necrotic pancreatitis was performed with the study of the volume of the pancreatic lesion for a period of 6 hours from the moment of modeling; Group D (n = 6) in this group, the effect of Infliximab at a dose of 60 mkg/kg on mortality in severe destructive pancreatitis was studied for a period of 24 hours from the moment of modeling; Group E (n = 6) in this group, the effect of infliximab at a dose of 120 mkg/kg on the volume of pancreatic lesion in severe destructive pancreatitis was studied for a period of 6 hours from the moment of modeling. During the assessment of pancreatic damage, volume of pancreatic lesion was found that in a period of 6 h after modeling was at 34.8%±1.2% level. Assessment of pancreatic damage in group E, with studying the protective effect of Infliximab at a dose of 60 mg/kg, showed that the total volume of the necrotic pancreatic lesion after a period of 6 h from the moment of modeling of acute pancreatitis was 21.3%±1.4%. In the course of this study, it was revealed that the use of Infliximab at a dose of 60 mcg/kg leads to a pronounced positive effect on the pancreatic lesion, manifested by a decrease in mortality by 1 day in group D to 50%. Infliximab has a definite protective effect in acute pancreatitis, decreasing the volume of the injury and decreasing the mortality rate for 24 hours by half. Anti-TNF therapy with Infliximab can significantly reduce the volume of pancreatic lesions in severe forms of pancreatic necrosis, which contributes to a pronounced decrease in mortality for 1 day from the moment of reproduction of the pathology. | ||
| کلیدواژه‌ها | ||
| Severe Acute Necrotizing Pancreatitis؛ Volume of Pancreatic Damage؛ Infliximab | ||
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آمار تعداد مشاهده مقاله: 7 تعداد دریافت فایل اصل مقاله: 3 |
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