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آمار
| تعداد نشریات | 278 |
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Study of the Nephroprotective Properties of the Erythropoietin Mimetic Peptide and Infliximab in Kidney Ischemia-Reperfusion Injury in Rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 شهریور 1400 اصل مقاله (559.3 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.355849.1728 | ||
| نویسندگان | ||
A S. Netrebenko  ؛ V V. Gureev؛ M V. Pokrovskii؛ A V. Gureeva؛ Y M. Tsuverkalova؛ I S. Rozhkov
| ||
| Belgorod State University, 85 Pobeda St., Belgorod, 308015, Russia | ||
| چکیده | ||
| Chronic kidney disease (CKD) or acute kidney injury (AKI) causes impaired kidney function, leading to cognitive impairment, neuropathy, and cerebrovascular disease. Due to kidney damage, toxins from the blood are not able to leave the body and affect brain function through kidney-brain interaction. This study was performed to investigate the protective effects of the fungal peptide erythropoietin (pHBSP) and infliximab on ischemic renal reperfusion injury. The experiment was performed on 70 white male Wistar laboratory rats. Animals were administered with recombinant erythropoietin, erythropoietin mimetic peptide (pHBSP), and infliximab. Under anesthesia, traumatic vascular clamps were applied to the left renal pedicle for 40 minutes, and a nephrectomy was performed on the right. Functional tests and laboratory tests were performed 5 minutes and 24 hours after the reperfusion. Twenty-four hours after the surgery, the plasma creatinine and urea levels in the sham-operated animals were 45.9±0.8 mmol/L and 6.7±0.2 mmol/L, respectively. Plasma creatinine and urea levels in the control group animals were 102.63±3.6 mmol/L and 21.80±1.29 mmol/L, respectively. The administration of erythropoietin mimetic peptide (pHBSP) and infliximab to the animals with ischemia-reperfusion kidney injury has a pronounced nephroprotective effect comparable to erythropoietin. There was a significant decrease in blood levels of creatinine and urea, improvement of microcirculation in the kidney, normalization of glomerular filtration rate, and fractional sodium excretion. The results of the study show the prospects of erythropoietin mimetic peptide (pHBSP) and infliximab administration in ischemia-reperfusion kidney injury and justify the feasibility of further research in this direction. | ||
| کلیدواژه‌ها | ||
| Erythropoietin mimetic peptide (pHBSP)؛ Infliximab؛ Ischemia-reperfusion kidney injury؛ Rats؛ Microcirculation | ||
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آمار تعداد مشاهده مقاله: 6 |
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