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| تعداد نشریات | 278 |
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| تعداد شماره‌ها | 2,179 |
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Evaluation of Morphological and Histological Changes of Aggregated Lymph Nodes in the Small Intestine After Imofan Treatment in Immunosuppressed Rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 شهریور 1400 اصل مقاله (735.44 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.355816.1724 | ||
| نویسندگان | ||
E N. Morozova  ؛ V N. Morozov؛ A V. Tverskoi؛ S N. Perepelkina؛ V P. Konshina
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| Belgorod State University, 308015, Russia, Belgorod, Pobeda St. 85 | ||
| چکیده | ||
| Diffuse nodular lymphoid hyperplasia is a rare gastrointestinal disease that can be diagnosed by multiple nodules in the small intestine, large intestine, or both. Immunodeficiency and infections are the common situations which lead to the diffuse nodular lymphoid hyperplasia. For instance Giardia lamblia and Helicobacter pylori are the major pathogens cussing to this disorder. Diffuse nodular lymphoid hyperplasia leads to allergic reactions, immunodeficiency, and autoimmune diseases.Imunofan-RDKVYR Peptide-is a potential agent in regenerative medicine. The aim of thecurrent study was to investigate morphological features of the small intestine’s aggregated lymphoid nodules after the Imunofan(IM)administration following Cyclophosphamide-induced immunosuppression. Seventy two Wistar male rats randomly divided into 2 groups(n=36).Group I was considered as the control group. Group I was administered to intramuscular injections (needle 21 G) of0.2 ml of normal saline following the Cyclophosphamide-induced immunosuppression on the2nd, 4th, 6th, 8th, 10th days of the experiment. The animals in group IIwere injected with Cyclophosphamide at a dose of 200 mg/kg body weight to induce immunosuppression. The animals in the experimental group (n=36) were administered to intramuscular injections (needle 21 G)of the0.2 ml IM at a dose of 0.7μg/kg body weighton the 2nd, 4th, 6th, 8th, 10th days of the experiment. The results of the study showed that on the 7th day in group II the length, width of the aggregated lymphoid nodules increases, as well as the height and width of the lymphoid nodules and internodular zones as structural components of the lymphoid formations in the small intestine. In group Ibythe 30th days of the experiment, the linear dimensions of the aggregated lymphoid nodules exceed, but to a lesser extent than on the 7th days of the experiment, which explains the ability of IM to neutralize the effects of Cyclophosphamide. It should also be noted that the IM was performed to regenerate damaged cells, which helped maintain the population of lymphocytes in the limb and led to an increase in linear dimensions (length and width) not only between the joint and also the lymph nodes. | ||
| کلیدواژه‌ها | ||
| Aggregated lymphoid nodules؛ Cyclophosphamide؛ Imunofan؛ Rats؛ Small intestine | ||
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