Evaluation of the neuroprotective effect of Magnesium-Bis-(2-Aminoethanesulfonic)-butadioate in simulated ischemic stroke in rats

I. Nesterova, N; V. Pokrovskii, V; A. Patrakhanov, E; V. Pirozhkov, I; G. Pokrovskaya, T; B. Levit, N; M.I, I; N.M Kizi, S; V. Nesterov, A; I. Shutov, V; A. Hoshchenko, Y

doi:10.22092/ari.2021.355813.1723

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	Evaluation of the neuroprotective effect of Magnesium-Bis-(2-Aminoethanesulfonic)-butadioate in simulated ischemic stroke in rats
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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 شهریور 1400 اصل مقاله (484.48 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355813.1723
نویسندگان
N I. Nesterova ¹؛ V V. Pokrovskii²؛ E A. Patrakhanov²؛ I V. Pirozhkov¹؛ T G. Pokrovskaya²؛ N B. Levit¹؛ I M.I²؛ S N.M kizi²؛ A V. Nesterov¹؛ V I. Shutov³؛ Y A. Hoshchenko²
¹Regional State Funded Healthcare Facility “Belgorod Forensic Medical Bureau”, 159, Volchanskaya St., Belgorod, 308017, Russia
²Belgorod State National Research University, 85, Pobeda St., Belgorod, 308015, Russia
³Belgorod Regional Hospital of St. Joasaph, 8/9, Nekrasova St., Belgorod, 308036, Russia
چکیده
Sudden loss of blood flow to an area of the brain causes ischemic stroke, which leads to a loss of nerve function in the brain. The brain tissue leads to the death of brain cells in less than a few minutes due to the lack of oxygen and nutrients. This study aimed to evaluate the effectiveness of pharmacological correction of the consequences of ischemic stroke with a new derivative of taurine magnesium-bis-(2-aminoethanesulfonic)-butadioate under laboratory code LKHT 3-17 in rats. The ischemic stroke was simulated by electrocoagulation of the right middle cerebral artery. The assessment of lethality, neurological status, locomotor, and exploratory behavior, and morphological pattern of the brain damage was carried out on the 1st, 3rd, and 7th day after the pathology simulation. Neurological deficit was determined by the McGrow stroke index scale. The locomotor and exploratory behavior was evaluated using the Acti-track software and hardware complex. When assessing the morphological changes in the brain, attention was paid to two criteria: the average thickness of the brain cortex and the number of neurons without degenerative changes. The substances were administered 60 minutes before the start of surgery. The animals were divided into the following groups: Intact group (n=20); ischemic stroke simulation without pharmacological correction (n=50); a group with correction of the ischemic stroke with taurine at the dose of 50 mg/kg (n=50); a group with correction of ischemic stroke with magnesium-bis-(2-aminoethanesulfonic)-butadioate (LKHT 3-17) at the dose of 150 mg/kg (n=50)..
کلیدواژه‌ها
Ischemic Stroke؛ Taurine؛ Neuroprotection

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Evaluation of the neuroprotective effect of Magnesium-Bis-(2-Aminoethanesulfonic)-butadioate in simulated ischemic stroke in rats