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Gattea Al-Rikabi, Z, Abbas, A. H, Kadhum Oudah, H, Sajer Nassir, H, Ali, S. A. (1400). Histopathological Study of Liver and Kidney Tissues in C57 Mice via Chronic Exposure to Cadmium and Zinc. سامانه مدیریت نشریات علمی, 76(5), 1501-1508. doi: 10.22092/ari.2021.355622.1705
Z Gattea Al-Rikabi; A. H Abbas; H Kadhum Oudah; H Sajer Nassir; S. A Ali. "Histopathological Study of Liver and Kidney Tissues in C57 Mice via Chronic Exposure to Cadmium and Zinc". سامانه مدیریت نشریات علمی, 76, 5, 1400, 1501-1508. doi: 10.22092/ari.2021.355622.1705
Gattea Al-Rikabi, Z, Abbas, A. H, Kadhum Oudah, H, Sajer Nassir, H, Ali, S. A. (1400). 'Histopathological Study of Liver and Kidney Tissues in C57 Mice via Chronic Exposure to Cadmium and Zinc', سامانه مدیریت نشریات علمی, 76(5), pp. 1501-1508. doi: 10.22092/ari.2021.355622.1705
Gattea Al-Rikabi, Z, Abbas, A. H, Kadhum Oudah, H, Sajer Nassir, H, Ali, S. A. Histopathological Study of Liver and Kidney Tissues in C57 Mice via Chronic Exposure to Cadmium and Zinc. سامانه مدیریت نشریات علمی, 1400; 76(5): 1501-1508. doi: 10.22092/ari.2021.355622.1705

Histopathological Study of Liver and Kidney Tissues in C57 Mice via Chronic Exposure to Cadmium and Zinc

Archives of Razi Institute
مقاله 40، دوره 76، شماره 5، بهمن و اسفند 2021، صفحه 1501-1508    اصل مقاله (1.03 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355622.1705
نویسندگان
Z Gattea Al-Rikabi؛ A. H Abbas* ؛ H Kadhum Oudah؛ H Sajer Nassir؛ S. A Ali
Ministry of Sciences and Technology, Environment and Water Directorate, Baghdad, Iraq
چکیده
Heavy metals have a wide application in the industrial world, affecting the health and longevity of living organisms. The current study assessed the possible effects of Cadmium (Cd) and Zinc (Zn) on the liver and kidney. Therefore, 150 male and female white mice C57BL were treated in three different groups with 0.685 mg/L CdCl2. 2.5H2O (group 1), and 0.567 mg/L ZnSO4.7H2O (group 2) in drinking water, while the control group only received water for 90 days to investigate how these elements accumulated in the liver/kidney and evaluate the possible histological changes in the liver and kidney. During 90 days, the histopathological consequences of Cd and Zn on the liver and kidneys were recorded. The results pointed out that exposure to heavy metals, such as Cd and Zn, led to organ accumulation of these elements. The histological evaluations demonstrated significant detrimental effects on the liver and kidney. Under the influence of Cd, light microscopic examination revealed significant histological alterations in both organs. In the animals exposed to Cd and Zn, histopathological alterations were observed in the liver, including extensive degeneration, necrosis, depletion, and necrosis of hepatocytes with significant nuclear hypertrophy. When animals are exposed to Cd and Zn, histological alterations in the kidneys include severe vascular degeneration and renal tubule necrosis. In conclusion, heavy metal intoxication has been shown to cause histopathological changes in the liver and kidneys of experimental animal models.
کلیدواژه‌ها
Heavy metal؛ Accumulation؛ Liver؛ Kidney؛ Histopathology
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مراجع
  1. Sánchez-Bayo F. Sources and toxicity of pollutants. Ecological Impacts of Toxic Chemicals Online: Bentham Science Publishers. 2011:3-12.
  2. Nriagu JO. A global assessment of natural sources of atmospheric trace metals. Nature. 1989;338(6210):47-9.
  3. Prashanth L, Kattapagari KK, Chitturi RT, Baddam VRR, Prasad LK. A review on role of essential trace elements in health and disease. J Dr NTR Univ Health Sci. 2015;4(2):75.
  4. Abaspour Aporvari MH, Mamoei M, Tabatabaei Vakili S, Zareei M, Dadashpour Davachi N. The Effect of Oral Administration of Zinc Oxide Nanoparticles on Quantitative and Qualitative Properties of Arabic Ram Sperm and Some Antioxidant Parameters of Seminal Plasma in the Non-Breeding Season. Arch Razi Inst. 2018;73(2):121-9.
  5. Jezierska B, Witeska M. The metal uptake and accumulation in fish living in polluted waters. Soil and water pollution monitoring, protection and remediation: Springer; 2006. p. 107-14.
  6. Mahboob S, Kausar S, Jabeen F, Sultana S, Sultana T, Al-Ghanim K, et al. Effect of heavy metals on liver, kidney, gills and muscles of Cyprinus carpio and Wallago attu inhabited in the Indus. Braz Arch Biol Technol. 2016;59.
  7. Koyu A, Gokcimen A, Ozguner F, Bayram DS, Kocak A. Evaluation of the effects of cadmium on rat liver. Mol Cell Biochem. 2006;284(1):81-5.
  8. Yannai S, Sachs K. Absorption and accumulation of cadmium, lead and mercury from foods by rats. Food Chem Toxicol.1993;31(5):351-5.
  9. Abdel-Wahab A, Abdel-Razik A-RH, Aziz RLA. Rescue effects of aqueous seed extracts of Foeniculum vulgare and Carum carvi against cadmium-induced hepatic, renal and gonadal damage in female albino rats. Asian Pacific J Tropic med. 2017;10(12):1123-33.
  10. Odewumi CO, Badisa VL, Le UT, Latinwo LM, Ikediobi CO, Badisa RB, et al. Protective effects of N-acetylcysteine against cadmium-induced damage in cultured rat normal liver cells. Int J Mol Med. 2011;27(2):243-8.
  11. Crossgrove J, Zheng W. Manganese toxicity upon overexposure. NMR Biomed. 2004;17(8):544-53.
  12. Dos Santos Carvalho C, Fernandes MN. Effect of copper on liver key enzymes of anaerobic glucose metabolism from freshwater tropical fish Prochilodus lineatus. Comp Biochem Physiol A Mol Integr Physiol 2008;151(3):437-42.
  13. O’Brien TJ, Jiang G, Chun G, Mandel HG, Westphal CS, Kahen K, et al. Incision of trivalent chromium [Cr (III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease. Mutat Res Genet Toxicol Environ Mutagen. 2006;610(1-2):85-92.
  14. Siu ER, Mruk DD, Porto CS, Cheng CY. Cadmium-induced testicular injury. Toxicol Appl Pharmacol. 2009;238(3):240-9.
  15. Nordberg M. General aspects of cadmium: transport, uptake and metabolism by the kidney. Environ Health Perspect. 1984;54:13-20.
  16. Imed M, Fatima H, Abdelhamid K. Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver and kidney of the rat: histology and Cd accumulation. Food Chem Toxicol. 2008;46(11):3522-7.
  17. Mahran A, Osman H, El-Mawla A, Attia A. Protective effect of zinc (Zn) on the histology and histochemistry of liver and kidney of albino rat treated with cadmium. J Cytol Histol. 2011;2(4):2-9.
  18. Erdem O, Yazihan N, Kocak MK, Sayal A, Akcil E. Influence of chronic cadmium exposure on the tissue distribution of copper and zinc and oxidative stress parameters in rats. Toxicol Ind Health. 2016;32(8):1505-14.
  19. Satarug S, Nishijo M, Ujjin P, Moore MR. Chronic exposure to low-level cadmium induced zinc-copper dysregulation. J Trace Elem Med Biol. 2018;46:32-8.
  20. Saibu Y, Jamwal A, Feng R, Peak D, Niyogi S. Distribution and speciation of zinc in the gills of rainbow trout (Oncorhynchus mykiss) during acute waterborne zinc exposure: Interactions with cadmium or copper. Comp Biochem Physiol Part-C: Toxicol Pharmacol. 2018;206:23-31.
  21. Abdel-Daim MM, Abuzead SM, Halawa SM. Protective role of Spirulina platensis against acute deltamethrin-induced toxicity in rats. PloS One. 2013;8(9): 72991.
  22. Gathwan KH, Al Ameri QMA, Zaidan HK, Al Saadi AH, Ewadh MJ. Heavy metals induce apoptosis in liver of mice. Inter J Appl Biol Pharmacol Technol. 2012;3(2):146-50.
  23. Brzoska M, Moniuszko-Jakoniuk J, Piłat-Marcinkiewicz B, Sawicki B. Liver and kidney function and histology in rats exposed to cadmium and ethanol. Alcohol Alcohol. 2003;38(1):2-10.
  24. Mohapatra AK, Datta S, Kumari P. Genotoxic and histopathological effects of cadmium in male swiss albino mice, Mus musculus. BioScan. 2013;8(2):391-401.
  25. El-Refaiy AI, Eissa FI. Histopathology and cytotoxicity as biomarkers in treated rats with cadmium and some therapeutic agents. Saudi J Biol Sci. 2013;20(3):265-80.
  26. Omar A. Histopathological and physiological effects of liver and kidney in rats exposed to cadmium and ethanol. Glob Adv Res J Environ. 2013;2(3):93-106.
  27. Herak-Kramberger CM, Brown D, Sabolić I. Cadmium inhibits vacuolar H+-ATPase and endocytosis in rat kidney cortex. Kidney Int. 1998;53(6):1713-26.
  28. Garba SH. Toxicological Effects of Inhaled Mosquito Coil Smoke on the Rat Spleen: A Haematological and Histological Study" SH Garba," MM Shehu and “AB Adelaiye. J Med Sci. 2007;7(1):94-9.
  29. Jemai H, Lachkar HA, Messaoudi I, Kerkeni A. Effects of zinc pre-treatment on blood glutathione, serum zinc and kidney histological organisation in male rats exposed to cadmium. J Trace Elem Med Biol.2010;24(4):277-82.
  1. Renugadevi J, Prabu SM. Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol. 2010;62(2):171-81.
  2. Hefny HA, Ahmed SH. Histopatological effect of CdSo4 on foetal liver, kidneys and heart of albino rats. Egyptian British biol. 2004;6:111-8.
  3. Wang Y, Tang Y, Li Z, Hua Q, Wang L, Song X, et al. Joint toxicity of a multi-heavy metal mixture and chemoprevention in sprague dawley rats. Int J Environ Res Public Health 2020;17(4):1451.
  4. Desta G, Selemun H, Mekbeb A, Abraha T, Mihret G. Histopathological effects of cadmium on liver, kidneys and testis. Asian J SciTechnol. 2018;09(17):8355-60.
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