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Sanad, N. H, Abbas, H. R, Yaseen, A. A, Habeeb, I. A, Alsalim, H. A. (1400). Hormonal, Histological, and Comparative Study of the Effect of Pure Ginseng on Testicular Function in the Breeding/Non-Breeding Season of Rams in Basrah. سامانه مدیریت نشریات علمی, 76(5), 1519-1535. doi: 10.22092/ari.2021.355554.1697
N. H Sanad; H. R Abbas; A. A Yaseen; I. A Habeeb; H. A Alsalim. "Hormonal, Histological, and Comparative Study of the Effect of Pure Ginseng on Testicular Function in the Breeding/Non-Breeding Season of Rams in Basrah". سامانه مدیریت نشریات علمی, 76, 5, 1400, 1519-1535. doi: 10.22092/ari.2021.355554.1697
Sanad, N. H, Abbas, H. R, Yaseen, A. A, Habeeb, I. A, Alsalim, H. A. (1400). 'Hormonal, Histological, and Comparative Study of the Effect of Pure Ginseng on Testicular Function in the Breeding/Non-Breeding Season of Rams in Basrah', سامانه مدیریت نشریات علمی, 76(5), pp. 1519-1535. doi: 10.22092/ari.2021.355554.1697
Sanad, N. H, Abbas, H. R, Yaseen, A. A, Habeeb, I. A, Alsalim, H. A. Hormonal, Histological, and Comparative Study of the Effect of Pure Ginseng on Testicular Function in the Breeding/Non-Breeding Season of Rams in Basrah. سامانه مدیریت نشریات علمی, 1400; 76(5): 1519-1535. doi: 10.22092/ari.2021.355554.1697

Hormonal, Histological, and Comparative Study of the Effect of Pure Ginseng on Testicular Function in the Breeding/Non-Breeding Season of Rams in Basrah

Archives of Razi Institute
مقاله 42، دوره 76، شماره 5، بهمن و اسفند 2021، صفحه 1519-1535    اصل مقاله (1.23 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.355554.1697
نویسندگان
N. H Sanad* ؛ H. R Abbas؛ A. A Yaseen؛ I. A Habeeb؛ H. A Alsalim
Department of Surgery and Obstetric/Theriogenology, College of Veterinary Medicine, University of Basrah, Basrah, Iraq
چکیده
This study aimed to investigate the effect of the administration of powdered Panax ginseng as a dietary supplement on testosterone concentration, spermatogenesis stimulating hormone, interstitial cell-stimulating hormone levels, sperms morphological characteristics, testis histological traits, and testicular size in the breeding and non-breeding season in adult rams. In total, 20 adult rams were included and randomly divided into three groups. The first group of adult rams (n=8) was subdivided into two subgroups of four rams (Sub-G1-B and Sub-G2-B). TheSub-G1-B and Sub-G2-B were fed 2 and 5 g of P. ginseng once a day, respectively, for 90 days during the breeding season. The second group of adult rams (n=8) was subdivided into two subgroups of four rams (Sub-G1-NB and Sub-G2-NB). The Sub-G1-NB and Sub-G2-NB were fed 2 and 5 g of P. ginseng once a day, respectively, for 90 days during the non-breeding season. The third group of adult rams (n=4) was considered the control group two times (in and out of the season). The results showed that the testosterone concentration and gonad protective and interstitial cell-stimulating hormone levels increased significantly (P<0.05) in both the experimental groups that received ginseng supplementation, compared to the control group in and out of the breeding season. The evaluation of sperm morphometric parameters, such as total sperm count, total motility, and progressive motility, showed superiority in improving the above-mentioned parameters. However, the total immotile sperms and non-progressive sperms underwent a significant decrease (P<0.05) in both experimental groups of ginseng supplemented, compared to the control group in and out of season. The angiogenesis of the seminiferous tubules increased significantly (P<0.05) in both experimental groups. Through a microscopic examination, the recorded data showed a significant increase in the population of spermatogonial stem cells as well as primary and secondary spermatocytes in both experimental groups. Values of testicular diameter showed a significant increase (P<0.05) after a period of 75 and 90 days following the initiation of treatments in both experimental groups, compared to the control group in and out of the season. It can be concluded that P. ginseng has some beneficial effects on the antioxidant status of the semen, the morphometric parameters, and other critical traits of sperm and testicles which are the important factors in male fertility.
کلیدواژه‌ها
ICSH؛ Panax ginseng؛ Ram؛ SSH؛ Testis؛ Testosterone
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مراجع
  1. Dadashpour Davachi N, Zare Shahneh A, Kohram H, Zhandi M, Dashti S, Shamsi H, et al. In vitro ovine embryo production: the study of seasonal and oocyte recovery method effects. Iran Red Crescent Med J. 2014;16(9):e20749.
  2. Barto·íková L, Such¯ V, Kubinova R, Jankovská D, Bene· L, Illek J, et al. Antioxidative Effects of Morine in Ischemia-Reperfusion of Kidneys in the Laboratory Rat. Acta Veterinaria Brno. 2003;72.
  3. Lokey E, Tran Z. Free radicals, insulin actionand diabetes in superoxide dismutase. Boca Raton FL CRC. 1989;111:151-90.
  4. Hassan H. Chemical composition and nutritional value of palm pollen grains. Global J Biotechnol Biochem. 2011;6:1-7.
  5. Yesilbag D, Gezen SS, Biricik H, Meral Y. Effects of dietary rosemary and oregano volatile oil mixture on quail performance, egg traits and egg oxidative stability. Br Poult Sci. 2013;54(2):231-7.
  6. Bae EA, Han MJ, Kim EJ, Kim DH. Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. Arch Pharm Res. 2004;27(1):61-7.
  7. Pak SC, Lim SC, Nah SY, Lee J, Hill JA, Bae CS. Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries. Fertil Steril. 2005;84(2):1139-43.
  8. Bak MJ, Hong SG, Lee JW, Jeong WS. Red ginseng marc oil inhibits iNOS and COX-2 via NFkappaB and p38 pathways in LPS-stimulated RAW 264.7 macrophages. Molecules. 2012;17(12):13769-86.
  9. Kim DH, Moon YS, Lee TH, Jung JS, Suh HW, Song DK. The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice. Neurosci Lett. 2003;353(1):13-6.
  10. Lin QY, Jin LJ, Cao ZH, Xu YP. Inhibition of inducible nitric oxide synthase by Acanthopanax senticosus extract in RAW264.7 macrophages. J Ethnopharmacol. 2008;118(2):231-6.
  11. Nah SY, Bhatia KS, Lyles J, Ellinwood EH, Lee TH. Effects of ginseng saponin on acute cocaine-induced alterations in evoked dopamine release and uptake in rat brain nucleus accumbens. Brain Res. 2009;1248:184-90.
  12. De Souza LR, Jenkins AL, Jovanovski E, Rahelic D, Vuksan V. Ethanol extraction preparation of American ginseng (Panax quinquefolius L) and Korean red ginseng (Panax ginseng C.A. Meyer): differential effects on postprandial insulinemia in healthy individuals. J Ethnopharmacol. 2015;159:55-61.
  13. Ye R, Yang Q, Kong X, Han J, Zhang X, Zhang Y, et al. Ginsenoside Rd attenuates early oxidative damage and sequential inflammatory response after transient focal ischemia in rats. Neurochem Int. 2011;58(3):391-8.
  14. Dadashpour Davachi N, Bartlewski P, Masoudi R, Ahmadi B, Didarkhah M. Induction of ovulation after artificial insemination in rabbits: Intramuscular injection of gonadotropin-releasing hormone (GnRH) agonist vs. intravenous administration of mated doe serum. Iran J Vet Med. 2021.
  15. Habeeb I, Al-Sariy S. Effect Scoring Method on Oocyte Maturation, Fertilization and Development Embryo Production from Local Buffalo Oocyte. Iraqi J Vet Sci. 2019;43(1):130-7.
  16. Salvati G, Genovesi G, Marcellini L, Paolini P, De Nuccio I, Pepe M. Effects of Panax Ginseng CA Meyer saponins on male fertility. Panminerva medica. 1996;38(4):249-54.
  17. Jae-Gook S. Protective Effects of a Ginseng Component, Malto1 (2-Mlethyl-3-Hydrox)-4-Pyrone) against Tissue Damages InducedBy Oxygen Radicals. J Ginseng Res. 1990;14(2):187-90
  18. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999;58(11):1685-93.
  19. Solakidi S, Psarra AM, Nikolaropoulos S, Sekeris CE. Estrogen receptors alpha and beta (ERalpha and ERbeta) and androgen receptor (AR) in human sperm: localization of ERbeta and AR in mitochondria of the midpiece. Hum Reprod. 2005;20(12):3481-7.
  20. Liu ZQ, Luo XY, Liu GZ, Chen YP, Wang ZC, Sun YX. In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes. J Agric Food Chem. 2003;51(9):2555-8.
  21. Hong B, Ji YH, Hong JH, Nam KY, Ahn TY. A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol. 2002;168(5):2070-3.
  22. Linjawi S. Evaluation of the Protective Effect of Panax Ginseng Nanoparticles against Nicotine-induced Reproductive Disorders in Male Rats. J Pharm Sci Rev Res. 2015;32(1):38-45.
  23. Rim BM. Ultrastructural studies on the effects of Korean Panax ginseng on the theca interna of rat ovary. Am J Chin Med. 1979;7(4):333-44.
  24. Benishin CG. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochem Int. 1992;21(1):1-5.
  25. Shi J, Xue W, Zhao WJ, Li KX. Pharmacokinetics and dopamine/acetylcholine releasing effects of ginsenoside Re in hippocampus and mPFC of freely moving rats. Acta Pharmacol Sin. 2013;34(2):214-20.
  26. Tsai S-C, Chiao Y-C, Lu C-C, Wang P. Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats. Chin J Physiol. 2003;46:1-7.
  27. Mandiki SNM, Derycke G, Bister JL, Paquay R. Influence of season and age on sexual maturation parameters in Texel, Suffolk and Ile-de-France rams: 2. Circulating concentrations of follicle stimulating hormone, luteinizing hormone, prolactine and testosterone. Small Rumin Res. 1998;28(1):81-8.
  28. Dahlberg B. Sperm motility in fertile men and males in infertile units: in vitro test. Arch Androl. 1988;20(1):31-4.
  29. Morgentaler A, Fung MY, Harris DH, Powers RD, Alper MM. Sperm morphology and in vitro fertilization outcome: a direct comparison of World Health Organization and strict criteria methodologies**Presented in part at the Meeting of the American Urological Association, San Antonio, Texas, May 15 to 20, 1993. Fertil Steril. 1995;64(6):1177-82.
  30. Park JS, Hwang SY, Lee WS, Yu KW, Paek KY, Hwang BY, et al. The therapeutic effect of tissue cultured root of wild Panax ginseng C.A. Mayer on spermatogenetic disorder. Arch Pharm Res. 2006;29(9):800-7.
  31. Yang WM, Park SY, Kim HM, Park EH, Park SK, Chang MS. Effects of Panax ginseng on glial cell-derived neurotrophic factor (GDNF) expression and spermatogenesis in rats. Phytother Res. 2011;25(2):308-11.
  32. Eskandari M, Ghalyanchi Langeroudi A, Zeighami H, Rostami A, Kazemi M, Eyni H, et al. Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats. Andrologia. 2017;49(3).
  1. Park EH, Kim DR, Kim HY, Park SK, Chang MS. Panax ginseng induces the expression of CatSper genes and sperm hyperactivation. Asian J Androl. 2014;16(6):845-51.
  2. Miri M, Shokri S, Darabi S, Heidari M, Ghalyanchi A, Karimfar M, et al. Efficacy of Compound Therapy by Ginseng and Ciprofloxacin on Bacterial Prostatitis. Cell J. 2016;18:103-11.
  3. Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol. 2008;66(4):444-50.
  4. Leung KW, Wong AS. Ginseng and male reproductive function. Spermatogenesis. 2013;3(3):e26391.
  5. Massa R, Davies DT, Bottoni L. Cloacal gland of the Japanese quail: androgen dependence and metabolism of testosterone. J Endocrinol. 1980;84(2):223-30.
  6. Sturkie PD. Heart and Circulation: Anatomy, Hemodynamics, Blood Pressure, Blood Flow. In: Sturkie PD, editor. Avian Physiol. New York, NY: Springer New York; 1986. p. 130-66.
 

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