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آمار
| تعداد نشریات | 278 |
| تعداد نشریات سازمان | 77 |
| تعداد شماره‌ها | 2,175 |
| تعداد مقالات | 25,182 |
| تعداد مشاهده مقاله | 13,619,418 |
| تعداد دریافت فایل اصل مقاله | 10,947,616 |
Improvement of the Selectivity Index (SI) and Cytotoxicity Activity of Doxorubicin Drug by Panax ginseng plant Extract | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 15 مرداد 1400 اصل مقاله (673.85 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.355413.1681 | ||
| نویسندگان | ||
M Radha Abbas Hasoon؛ Naser Jawad Kadhim 
| ||
| Assistant Lecturer at university of Kufa, Faculty of Science, Department of Biology, Iraq | ||
| چکیده | ||
| In China, Japan, and Korea Panax ginseng has been used in traditional medicine for thousands of years. Panax is a plant that is used as a general tonic or adaptogen with chronically ill patients. In the current study the cytotoxicity of Panax ginseng extract (PGE) is evaluated. Different cell lines (HCT-116, LNCaP, and normal cell line VERO) was treated with different inhibitory agent with different concentrations (1000, 500, 250, 125, 62.5, and 31.25 µg/ml) as follows: G1 (Methanol Panax ginseng extract, PGE), G2 (Doxorubicin, DOX), G3 (Methanol Panax ginseng extract +DOX, PDD), Each inhibitory agent groups used to treat the cancerous cell lines HCT-116, LNCaP, and normal cell line (VERO) to obtain IC50% by MTT assay. The inhibitory ability of the 1000 μg/ml PGE was significantly increased in all the three-cell lines compared with other concentrations. The recorded data revealed that the inhibition ability of the PGE and Doxorubicin towards HCT-116 cell line significantly increased compared with the other cell lines. The interaction between different PGE concentrations and cell lines showed that the 1000 μg/ml PEG had the highest inhibitory effects on HCT-116 compared with other combinations. While the interaction between different DOX concentrations and different types of cell lines showed that the 1000 μg/ml DOX had the highest inhibitory effects on LNCap compared with other combinations. The PGD inhibition ability reflected a higher significant difference towards HCT-116 cell line as compared with other cell lines. The IC50% is the concentrations (µg/ml) to kill 50% of cell line, it was calculated by MTT assay for three cell lines, two cancerous cell lines; HCT-116, LNCaP, and VERO. The rate of effectiveness of the inhibitory factors (PGE, DOX, and PGD), showed high significant differences towards the cell line HCT-116 compared to the other cell lines. This indicates the safety of PGE compound and their low toxicity towards normal cells quite the opposite of cancer cells as compared to the common drug DOX and combined PGD (PGE+DOX). The combined PGD with DOX (PGE + DOX) showed antagonistic results towards the HCT116, LNCaP, and VERO cell line, while the combined UDE with DOX (UDE+DOX) showed synergistic activity. | ||
| کلیدواژه‌ها | ||
| Panax ginseng؛ HCT-116؛ LNCap؛ VERO؛ doxorubicin؛ interaction index؛ selectivity index | ||
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آمار تعداد مشاهده مقاله: 81 تعداد دریافت فایل اصل مقاله: 20 |
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