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Rasheed, S., Younis, L., Aboud, Q.. (1400). Association between Bovine GDF9 SNPs and Calving Rate (Superovulation) in Holstein-Friesian Cows. سامانه مدیریت نشریات علمی, 76(4), 1035-1045. doi: 10.22092/ari.2021.354310.1632
S. T Rasheed; L. S Younis; Q. M Aboud. "Association between Bovine GDF9 SNPs and Calving Rate (Superovulation) in Holstein-Friesian Cows". سامانه مدیریت نشریات علمی, 76, 4, 1400, 1035-1045. doi: 10.22092/ari.2021.354310.1632
Rasheed, S., Younis, L., Aboud, Q.. (1400). 'Association between Bovine GDF9 SNPs and Calving Rate (Superovulation) in Holstein-Friesian Cows', سامانه مدیریت نشریات علمی, 76(4), pp. 1035-1045. doi: 10.22092/ari.2021.354310.1632
Rasheed, S., Younis, L., Aboud, Q.. Association between Bovine GDF9 SNPs and Calving Rate (Superovulation) in Holstein-Friesian Cows. سامانه مدیریت نشریات علمی, 1400; 76(4): 1035-1045. doi: 10.22092/ari.2021.354310.1632

Association between Bovine GDF9 SNPs and Calving Rate (Superovulation) in Holstein-Friesian Cows

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مقاله 33، دوره 76، شماره 4، آذر و دی 2021، صفحه 1035-1045    اصل مقاله (605.94 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.354310.1632
نویسندگان
S. T Rasheed1؛ L. S Younis* 2؛ Q. M Aboud2
1Veterinary College, Tikrit University, Tikrit, Iraq
2Veterinary College, Fallujah University, Baghdad, Iraq
چکیده
The present study aimed to assess the relationship of Growth Differentiation Factor 9 (GDF9) genotypes with calving rate, Follicle-stimulating hormone (FSH), and Estradiol (E2) in the Iraqi Holstein-Friesian breed. A number of 15 blood samples were collected from a mother of dizygotic twin birth (DZTB) (with high calving rate records), and another blood sample was collected from 15 single birth (SB) cows. The DNA was extracted and six primers were designed for PCR and sequencing analysis. The FSH and E2 levels were tested through the estrus phase for the two groups (n=10 in each group). The sequence evaluation revealed the presence of two single nucleotide polymorphisms (SNPs) in exon II: A (1109) T and G (1133) A. The genotypic frequency for mutant genotypes was higher significantly (P<0.01) in DZTB cows (with calving rate), as compared to wild genotypes at the same loci. On the other hand, the wild genotypes recorded a significant increment (P<0.01) for SB cows, when compared to mutant genotypes in the same loci. Moreover, a significant rise (P<0.05) was reported in E2 and FSH levels for DZTB cows and mutant genotypes (P<0.01) against SB cows and wild genotypes in 0 and 24 h of estrus phase, respectively. Furthermore, non-significant differences were recorded in E2 concentration among the same genotypes at the same period. In conclusion, the GDF9 exon II SNPs increased the calving rate in Holstein-Friesian cows. The blood FSH and E2 concentrations were higher in the DZTB cows and control the superovulation. Finally, these SNPs can be regarded as markers to accelerate the breeding programs and used in embryo transfer and in vitro embryo production for Iraqi Holstein-Friesian cow breed.
کلیدواژه‌ها
Calving rate؛ Dizygotic twinning؛ GDF9 polymorphism؛ FSH؛ Estradiol
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مراجع
  1. Juma K, Saad T, Tikriti A, editors. Performance of Brown Swiss and Friesian cattle in central Iraq. Proceeding of 4th world congress on genetics applied to Livestock production Edinburg UK; 1990.
  2. Hanrahan JP, Gregan SM, Mulsant P, Mullen M, Davis GH, Powell R, et al. Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries). Biol Reprod. 2004;70(4):900-9.
  3. Juengel JL, Hudson NL, Berg M, Hamel K, Smith P, Lawrence SB, et al. Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle. Reproduction. 2009;138(1):107-14.
  4. Haas C, Rovani MT, Oliveira F, Vieira A, Bordignon V, Gonçalves P, et al. Expression of growth and differentiation Factor 9 and cognate receptors during final follicular growth in cattle. Anim Reprod. 2016;13:756-61.
  5. Hosoe M, Kaneyama K, Ushizawa K, Hayashi KG, Takahashi T. Quantitative analysis of bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) gene expression in calf and adult bovine ovaries. Reprod Biol Endocrinol. 2011;9:33.
  6. Chen H, Liu C, Jiang H, Gao Y, Xu M, Wang J, et al. Regulatory Role of miRNA-375 in Expression of BMP15/GDF9 Receptors and its Effect on Proliferation and Apoptosis of Bovine Cumulus Cells. Cell Physiol Biochem. 2017;41(2):439-50.
  7. Dong J, Albertini DF, Nishimori K, Kumar TR, Lu N, Matzuk MM. Growth differentiation factor-9 is required during early ovarian folliculogenesis. Nature. 1996;383(6600):531-5.
  8. Spicer LJ, Aad PY, Allen DT, Mazerbourg S, Payne AH, Hsueh AJ. Growth differentiation factor 9 (GDF9) stimulates proliferation and inhibits steroidogenesis by bovine theca cells: influence of follicle size on responses to GDF9. Biol Reprod. 2008;78(2):243-53.
  9. Choi SG, Wang Q, Jia J, Pincas H, Turgeon JL, Sealfon SC. Growth differentiation factor 9 (GDF9) forms an incoherent feed-forward loop modulating follicle-stimulating hormone beta-subunit (FSHbeta) gene expression. J Biol Chem. 2014;289(23):16164-75.
  10. Marchitelli C, Nardone A. Mutations and sequence variants in GDF9, BMP15, and BMPR1B genes in Maremmana cattle breed with single and twin births. Rendiconti Lincei. 2015;26(3):553-60.
  11. Santos-Biase WK, Biase FH, Buratini J, Jr., Balieiro J, Watanabe YF, Accorsi MF, et al. Single nucleotide polymorphisms in the bovine genome are associated with the number of oocytes collected during ovum pick up. Anim Reprod Sci. 2012;134(3-4):141-9.
  12. Van Tassell CP, Van Vleck LD, Gregory KE. Bayesian analysis of twinning and ovulation rates using a multiple-trait threshold model and Gibbs sampling. J Anim Sci. 1998;76(8):2048-61.
  13. Karlsen A, Ruane J, Klemetsdal G, Heringstad B. Twinning rate in Norwegian cattle: frequency, (co)variance components, and genetic trends. J Anim Sci. 2000;78(1):15-20.
  14. Echternkamp S, Gregory K. Reproductive, growth, feedlot, and carcass traits of twin vs single births in cattle1,2. J Anim Sci. 2002;80.
  15. Hopper RM. Bovine Reproduction: Wiley; 2014.
  16. Tang KQ, Yang WC, Li SJ, Yang LG. Polymorphisms of the bovine growth differentiation factor 9 gene associated with superovulation performance in Chinese Holstein cows. Genet Mol Res. 2013;12(1):390-9.
  1. Souza CJ, McNeilly AS, Benavides MV, Melo EO, Moraes JC. Mutation in the protease cleavage site of GDF9 increases ovulation rate and litter size in heterozygous ewes and causes infertility in homozygous ewes. Anim Genet. 2014;45(5):732-9.
  2. Reineri PS, Coria MS, Barrionuevo MG, Hernández O, Callejas S, Palma GA. Gene expression of growth factor BMP15, GDF9, FGF2 and their receptors in bovine follicular cells. Rev MVZ Córdoba. 2018;23:6778-87.
  3. Lopez H, Sartori R, Wiltbank MC. Reproductive hormones and follicular growth during development of one or multiple dominant follicles in cattle. Biol Reprod. 2005;72(4):788-95.
  4. Lambalk CB, Boomsma DI, De Boer L, De Koning CH, Schoute E, Popp-Snijders C, et al. Increased levels and pulsatility of follicle-stimulating hormone in mothers of hereditary dizygotic twins. J Clin Endocrinol Metab. 1998;83(2):481-6.
  5. Martin NG, El Beaini JL, Olsen ME, Bhatnagar AS, Macourt D. Gonadotropin levels in mothers who have had two sets of DZ twins. Acta Genet Med Gemellol (Roma). 1984;33(1):131-9.
  6. Hafez E, Hafez B, editors. Twinning and Embryo Manipulation In Reproduction in farm animals. 3d Eds ed: John Wiley & Sons; 2013
  7. Hesser MW, Morris JC, Gibbons JR. Advances in recombinant gonadotropin production for use in bovine superovulation. Reprod Domest Anim. 2011;46(5):933-42.
  8. Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ. Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15. Mol Endocrinol. 2010;24(12):2303-14.
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