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Antiviral Effects of Aloe vera (L.) Burm.f. and Ruta Graveolens L. Extract on Acyclovir-Resistant Herpes Simplex Virus Type 1 | ||
| Journal of Medicinal plants and By-product | ||
| مقاله 13، دوره 10، شماره 1، تیر 2021، صفحه 103-108 اصل مقاله (294.7 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22092/jmpb.2021.352463.1286 | ||
| نویسندگان | ||
| Elahe Ebrahimi1؛ Seyed Milad Mousavi-Jazayeri2؛ Mohammad-Bagher Rezaee3؛ Masoud Parsania* 4 | ||
| 1Department of Microbiology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran | ||
| 2Department of Microbiology, Islamic Azad University, Science and Research Branch, Gilan, Iran | ||
| 3Department of Medicinal Plants, Research Institute of Forests and Rangelands, Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran | ||
| 4Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran | ||
| چکیده | ||
| Herpes simplex virus type I (HSV-1) is a causative agent in a wide range of human diseases. With increasing drug resistance to anti-viral drugs, numerous studies are under way, particularly on medicinal plants. In this study, therefore, the effects of Aloe vera (L.) Burm. f.and Ruta graveolens L. (R. graveolens) extracts were evaluated on acyclovir-resistant HSV-1. The toxicity of extracts from A. Vera and R. graveolens, and also acyclovir was evaluated on HeLa cells by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay to obtain the highest non-toxic concentrations of the extracts and acyclovir on the cells. The effects of extracts and acyclovir HSV-1 were examined at different concentrations during a range of times. The virus titers were measured at different stages of the study using the TCID50 method. Minimum cytotoxic concentrations (MCC) of 12000 μg/ml and 125 μg/ml were determined for A. vera and R. graveolens extracts respectively. R. graveolens extract with a SI (Stimulation Index) of 15.33 had a higher antiviral effect than A. vera. extract with 3 log TCID50 in 1 h and R. graveolens extract with 1.9 log TCID50 in 2 h after cell infection reduced the virus titer compared to the control. None of the tested concentrations of acyclovir had inhibitory effects on the virus replication. The extract of both plants had antiviral effects, but the extract of R. graveolens showed a higher antiviral impact on acyclovir-resistant HSV-1 compared to A. vera extract. | ||
| کلیدواژه‌ها | ||
| Herpes simplex virus type 1؛ Aloe vera؛ Ruta graveolens؛ Antiviral effects | ||
| مراجع | ||
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1. Hudson JB, Lee MK, Rasoanaivo P. Antiviral Activity in Plants Endemic to Madagascar. Pharm Biol. 2000;38:36-39.
2. Yuan R, LinY.Traditional Chinese Medicine: an approach to Scientific Proof and Clinical Validation. Clin Pharmacol Ther. 2000;86:191-198.
3. Akram M, Tahir IM, Shah SM, A, Mahmood Z, Altaf A, Ahmad K, Munir N, Daniyal M, Nasir S, Mehboob H. Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review. Phytother Res. 2018;5:811-822.
4. Straface G, Selmin A, et al. Herpes Simplex Virus Infection in Pregnancy. Infect Dis Obstet Gynecol. 2012;2012:1-6.
5. Chaabane S, Harfouche M, Chemaitelly H, Schwarzer G ,Abu-Raddad LJ. Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions. Sci. Rep. 2019;9:1136.
6. Declercq E.Antiviral Drugs in Current Clinical use Review. J Clin Virol. 2004;30:115-133.
7. Baghian A, Chouljenko VN, Dauvergne O, Newmant MJ, Baghian S , Kousoulas KG.Protective Immunity Against lethal HSV-1 challenge in mice by Nucleic Acid-Based Immunization with Herpes Simplex Virus Type-1 Genes Specifyin Glycoproteins gB and gD.J Med Microbiol. 2002;51:350-7.
8. Abad MJ, Bermejo P, Villar A, Sanchez-Palomino S , Carrasco L.Antiviral activity of Medicinal Plant Extracts. Phytother Res. 1997;11:198-202.
9. Vanden Berghe D, Vlietinick AJ, Van Hoof L.Plant Products as Potential Antiviral Agents. Bull Inst Pasteur. 1986;84:101-105.
10. Rajeswari R, Umadevi M, Sharmila Rahale C, Pushpa R, Selvavenkadesh S, Sampath Kumar KP, Bhowmik D.Aloe vera: The Miracle Plant Its Medicinal and Traditional Uses in India. J Pharmacogn Phytochem. 2012;1:118-124.
11. Rui Li, Meng-Yue W, Xiao-Bo Li. Review Chemical Constituents and Biological Activities of Genus Hosta (Liliaceae). J. Med. Plants Res. 2012:6;2704-2713.
12. Kambizi L, Goosenb BM, Tylorc, MB,Afolavana, AJ. Anti-viral Effects of Aqueous Extracts of Aloe Ferox and Withania somniferaon Herpes Simplex Virus Type 1 in Cellculture. S Afr J Sci. 2007:103:359-362.
13. Saklani A, Sahoo, MR, Kutty SK. The genus Ferillaria (Liliaceae): A review of its Phytochemical and Pharmacological Perspectives. Int J Pharmacogn Phytochem Res. 2011;1:96-111.
14. Hashemi, SA, Madani SA, Abediankenari S. Review Article The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds. Biomed Res Int. 2019;2015:75-77.
15. Surjushe A, Vasani R, Saple DG. Aloe vera: a short review. Indian J Dermatol. 2008;53:163-166.
16. Asgarpanah J, Khoshkam R. ReviewPhytochemistry and pharmacological properties of Ruta graveolensL. J Med Plants Res. 2012;6:3942-3949. (In Persian)
17. Naghibi Harat Z, Kamalinejad M, Sadeghi M, Sadeghipour H , Eshraghian M. A Review on Ruta graveolens L. Its Usage in Traditional Medicine and Modern Research Data. J Med Plants. 2009;2:1-19. (In Persian)
18-. Gentile MT, Ciniglia C, Reccia MG, Volpicelli F, Gatti M, Thellung S, Florio T, Melone MS, Colucci-D’Amato L. Ruta graveolens L. Induces Death of Glioblastoma Cells and Neural Progenitors, but Not of Neurons, via ERK 1/2 and AKT Activation. Plos One. 2015;10:1-17.
19. SeyedAlipour B, DelfanAzarian N, Asadi M, Mohseni M. Evaluation of Antibacterial Activity and Cytotoxicity of Ethanolic Extract of Lilium Ledbourii Bulbs on HeLa cell Line. J Res Med Sci. 2016;8:59-70. (In Persian)
20. Monavari H, Shamsi shahrabadi M,Vahabpour R, Azizi M. The effect of the Anti viral Nepeta Pungens on Measles virus in laboratory. Horizon Med Sci. 2011;16:1-8. (In Persian)
21. Sydiskis RJ, Owen DG, Lohr JL , Rosler K , Blomster HA, Blomaster RN .Inactivation of Enveloped Viruses by Anthraquinons Extracted from Plants. Antimicrob Agents Chemother. 1991;35:2463-2466.
22. Ramzi A, Mothana RM, Christiane R, Ulrike L.PHitochemical screening and Antiviral Activity of Some Medical Plants From The Island Soqotra . Phytother Res. 2006;20:298-302.
23. Yarmolinsky L, Zaccai M, Ben-Shabat S, Mills D, Huleihel M. Antiviral activity of Ethanol Extracts of Ficus Binjamina and Lilium Candidum in vitro. N Biotechnol. 2009;26:307-13.
24. Hayashi K, Nishino H, Niwayama S, Shiraki K, Hiramatsu A, etal.Yucca leaf protein (YLP) Stops The Protein Synthesis in HSV-1Infected Cells and Inhibits Virus Replication. Antiviral Res. 1992;17:323-30.
25. Zandi K, Abbas Zadeh M, Sartavi K, Rastian Z. Antiviral Activity of Aloe Vera Against Herpe Simplex Virus Type 2: An in Vitro Study. Afr J Biotechnol. 2007;6:1770-1773. (In Persian)
26. Wang W, Yuangang Zu, Yujie Fu, Reichling J. In Vitro Antioxidant, Antimicrobial and Anti-Herpes Simplex Virus Type 1 Activity of Phyllodendron amurense Rupr from China. Am J Chin Med. 2009;37:195-203. | ||
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