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Saghir, Farhat, Hussain, Khalid, Tahir, Muhammad Nawaz, Raza, Syed, Shehzadi, Naureen, Iftikhar, Sadaf, Shaukat, Ayisha, Naheed, Surriya, Siddique, Sidra. (1400). Antidiabetic Screening, Activity-guided Isolation and Molecular Docking Studies of Flower Extracts of Pongamia pinnata (L.) Pierre. سامانه مدیریت نشریات علمی, 10(1), 85-92. doi: 10.22092/jmpb.2020.343368.1222
Farhat Saghir; Khalid Hussain; Muhammad Nawaz Tahir; Syed Atif Raza; Naureen Shehzadi; Sadaf Iftikhar; Ayisha Shaukat; Surriya Naheed; Sidra Siddique. "Antidiabetic Screening, Activity-guided Isolation and Molecular Docking Studies of Flower Extracts of Pongamia pinnata (L.) Pierre". سامانه مدیریت نشریات علمی, 10, 1, 1400, 85-92. doi: 10.22092/jmpb.2020.343368.1222
Saghir, Farhat, Hussain, Khalid, Tahir, Muhammad Nawaz, Raza, Syed, Shehzadi, Naureen, Iftikhar, Sadaf, Shaukat, Ayisha, Naheed, Surriya, Siddique, Sidra. (1400). 'Antidiabetic Screening, Activity-guided Isolation and Molecular Docking Studies of Flower Extracts of Pongamia pinnata (L.) Pierre', سامانه مدیریت نشریات علمی, 10(1), pp. 85-92. doi: 10.22092/jmpb.2020.343368.1222
Saghir, Farhat, Hussain, Khalid, Tahir, Muhammad Nawaz, Raza, Syed, Shehzadi, Naureen, Iftikhar, Sadaf, Shaukat, Ayisha, Naheed, Surriya, Siddique, Sidra. Antidiabetic Screening, Activity-guided Isolation and Molecular Docking Studies of Flower Extracts of Pongamia pinnata (L.) Pierre. سامانه مدیریت نشریات علمی, 1400; 10(1): 85-92. doi: 10.22092/jmpb.2020.343368.1222

Antidiabetic Screening, Activity-guided Isolation and Molecular Docking Studies of Flower Extracts of Pongamia pinnata (L.) Pierre

Journal of Medicinal plants and By-products
مقاله 11، دوره 10، شماره 1، تیر 2021، صفحه 85-92    اصل مقاله (508.67 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22092/jmpb.2020.343368.1222
نویسندگان
Farhat Saghir* 1؛ Khalid Hussain1؛ Muhammad Nawaz Tahir2؛ Syed Atif Raza1؛ Naureen Shehzadi1؛ Sadaf Iftikhar1؛ Ayisha Shaukat1؛ Surriya Naheed1؛ Sidra Siddique1
1Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan
2Department of Physics, University of Sargodha, Sargodha, Pakistan
چکیده
Pongamia pinnata (L.) Pierre (Family: Fabaceae) is a famous traditional medicinal plant, the flowers of which are used for treating diabetes, however, the active constituent(s) is yet unidentified. Therefore, the present study aimed to carry out antidiabetic activity-guided isolation of extracts of flowers. Hexane extract being the most active (EC50, 900 µg/mL) was fractionated by partitioning and the most active hexane fraction (EC50, 570 µg/mL) was subjected to column chromatography which gave three isomers of compound 1 (4-Methoxy-7-phenyl-5H-furo [3,2-g][1] benzopyran-5-one), a furanoflavonoid. All the isomeric forms have equal antidiabetic activity (83.24%) with EC50 at 300 µg/mL.  The activity of the isolated compound was found to be higher as compared to standard drug acarbose (43.46%). Molecular docking studies of the compound indicated higher binding energy scores with antidiabetic targets as compared to the standard drug acarbose. The results of the present study indicate that the isolated compound may be developed into an antidiabetic drug.
کلیدواژه‌ها
Pongamia pinnata (L.) Pierre؛ diabetes؛ Column chromatography؛ Single-crystal X-ray diffraction (XRD)؛ Molecular docking studies
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