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Interconnection between Adrenergic and Dopaminergic Systems in Feeding Behavior in Neonatal Chicks | ||
| Archives of Razi Institute | ||
| مقاله 18، دوره 76، شماره 2، شهریور 2021، صفحه 345-358 اصل مقاله (724.6 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2020.341240.1425 | ||
| نویسندگان | ||
| F Zanganeh1؛ N Panahi* 1؛ M Zendehdel2؛ A Asghari3 | ||
| 1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran | ||
| 3Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| چکیده | ||
| Central dopaminergic (DAergic) and adrenergic systems have a prominent role in appetite regulation; however, their interaction(s) have not been studied in neonatal layer chickens.Therefore, the current study aimed to determine the interaction of central DAergic and noradrenergic systems in food intake regulation in neonatal layer chickens. In the first experiment, chickens received the intracerebroventricular (ICV) injection of a control solution, prazosin (i.e., α1 adrenergic receptor antagonist; 10 nmol), dopamine (DA; 40 nmol), and prazosin plus DA. The second to fifth experiments were similar to the first experiment except that the birds were injected with yohimbine (i.e., α2 receptor antagonist; 13 nmol), metoprolol (i.e., β1 adrenergic receptor antagonist; 24 nmol), ICI 118,551 (i.e., β2 adrenergic receptor antagonist; 5 nmol), and SR59230R (i.e., β3 adrenergic receptor antagonist; 20 nmol) instead of prazosin. In the sixth experiment, the chickens received ICV injection with the control solution and noradrenaline (NA; 75, 150, and 300 nmol). In the seventh experiment, the birds were injected with the control solution, SCH23390 (i.e., D1 DAergic receptor antagonist; 5 nmol), NA (300 nmol), and SCH23390 plus NA In the eighth experiment, the control solution, AMI-193 (i.e., D2 DAergic receptor antagonist; 5 nmol), NA (300 nmol), and AMI-193 plus NA were injected. Then, cumulative food intake was recorded at 30, 60, and 120 min after the injection. According to the obtained results, the ICV injection of DA (40 nmol) significantly decreased food intake in comparison to that reported for the control group (p <0.05). The co-injection of yohimbine plus DA significantly amplified DA-induced hypophagia in the neonatal chickens (p <0.05). In addition, the co-administration of ICI 118,551 plus DA significantly inhibited the hypophagic effect of DA in the neonatal chickens (p <0.05). Furthermore, NA (75, 150, and 300 nmol) significantly reduced food intake in a dose-dependent manner (p <0.05). The co-injection of SCH23390 plus NA decreased the hypophagic effect of NA in the neonatal chickens, compared to that reported for the control group (p <0.05). The co-injection of AMI-193 plus NA diminished NA-induced hypophagia, compared to that reported for the control group (p <0.05). The aforementioned results suggested that there is an interconnection between central DAergic and noradrenergic systems through α2/β2 adrenergic and D1/D2 DAergic receptors in food intake regulation in neonatal chicks. | ||
| کلیدواژه‌ها | ||
| Adrenergic؛ Dopamine؛ Food intake؛ Layer chicken | ||
| عنوان مقاله [English] | ||
| بررسی تداخل سیستم‌های دوپامینرژیک و آدرنرژیک مرکزی در تنظیم اخذ غذا در جوجه‌های نژاد تخمگذارD2 | ||
| چکیده [English] | ||
| سیستم‌های دوپامینرژیک و آدرنرژیک مرکزی نقش مهمی در تنظیم اشتها دارد اما تقابل عمل آنها در جوجه‌های تخمگذار بررسی نشده است. مطالعه حاضر به منظور بررسی سیستم‌های دوپامینرژیک و آدرنرژیک مرکزی در تنظیم اخذ غذا در جوجه‌های نژاد تخمگذار انجام گرفت. در آزمایش 1، جوجه-های 3 ساعت محروم از غذا، تزریقات داخل بطن مغزی (ICV) را به فرم زیر دریافت کردند: سالین، دوپامین (دوز 40 نانومول)، پرازوسین (آنتاگونیست گیرنده 1α ،10 نانومول) و دوپامین + پرازوسین. آزمایشات مراحل 2-5 مشابه آزمایش یک بود اما جوجه‌ها تزریق یوهمبین (آنتاگونیست گیرنده 2α، 13 نانومول)، متوپرولول (آنتاگونیست گیرنده 1β، دوز 24 میکروگرم)، ICI 118,551 (آنتاگونیست گیرنده 2β، دوز 15 نانومول) و SR 59230R (آنتاگونیست گیرنده 3β ، دوز 23 نانومول) را بجای پرازوسین دریافت کردند. در آزمایش 6، سالین، نور اپی نفرین (75 نانومول)، نور اپی نفرین (150 نانومول) و نور اپی نفرین (300 نانومول) تزریق شد. آزمایش 7، سالین، نور اپی نفرین (300 نانومول)، SCH23390 (آنتاگونیست گیرنده 1D دوپامینرژیک، دوز 5 نانومول) و نور اپی نفرین + SCH23390 تزریق شد. آزمایش 8، سالین، AMI-193 (آگونیست گیرنده‌های D2، 5 نانومول)، نور اپی نفرین (300 نانومول) و نور اپی نفرین + AMI-193 تزریق شد. سپس مصرف تجمعی غذا تا 120 دقیقه بعد از تزریق اندازه‌گیری شد. با توجه به نتایج بدست آمده، تزریق دوپامین (40 نانومول) موجب کاهش اخذ غذا شد (P≤0.05). تزریق توام yohimbin (13 نانومول) + دوپامین موجب تقویت اثرات هیپوفاژیک ناشی از دوپامین شد (P≤0.05). تزریق توام ICI 118,551 (5 نانومول) + دوپامین موجب مهار کاهش هیپوفاژیناشی از دوپامین شد (P≤0.05). مصرف غذا بواسطه تزریق داخل بطنی مغزی نورآدرنالین (75، 150 و 300 نانومول) به صورت وابسته به دوز کاهش یافت (P≤0.05). تزریق توام نورآدرنالین + SCH23390 موجب کاهش هیپوفاژی ناشی از نورآدرنالین شد (P≤0.05). تزریق توام AMI-193 + نورآدرنالین موجب مهار هیپوفاژی ناشی از نورآدرنالین شد (P≤0.05). نتایج نشان دهنده این بود که تقابل بین سیستم‌های آدرنرژیک و دوپامینرژیک از طریق گیرنده‌های 2α، 2β آدرنرژیک و D1و D2 دوپامینی در جوجه‌های تخمگذار میانجی‌گری می‌شود. | ||
| کلیدواژه‌ها [English] | ||
| سیستم دوپامینی, آدرنرژیک, اخذ غذا, جوجه تخمگذار | ||
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