| تعداد نشریات | 285 |
| تعداد نشریات سازمان | 83 |
| تعداد شماره‌ها | 3,084 |
| تعداد مقالات | 34,409 |
| تعداد مشاهده مقاله | 48,539,089 |
| تعداد دریافت فایل اصل مقاله | 79,132,587 |
Comparison of the Immunogenicity of Four Infectious Bursal Disease Intermediate Vaccines in Commercial Broiler Flocks in Iran: A Field Trial Study | ||
| Archives of Razi Institute | ||
| مقاله 8، دوره 75، شماره 2، شهریور 2020، صفحه 205-212 اصل مقاله (431.79 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2019.124890.1292 | ||
| نویسندگان | ||
| M. M. Ebrahimi* 1؛ A. R. Yousefi2؛ Sh. Shahsavadi1؛ M. Zaghari3؛ M. R. Bassami4 | ||
| 1Department of Poultry Viral Vaccines Research and Production, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran | ||
| 2Department of Pathology and Experimental Animals, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran | ||
| 3Department of Animal Sciences, College of Agriculture and Natural Resource, University of Tehran, Karaj, Iran | ||
| 4Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran | ||
| چکیده | ||
| Infectious bursal disease (IBD) is a highly contagious disease in young chickens worldwide. The major strategy for the prevention and control of IBD virus (IBDV) is vaccination. Therefore, the present study aimed to compare the immunogenicity of four commercially available IBD vaccines on broilers (Ross 308) that were raised in areas with very virulent IBDV infection history. Two commercial broiler farms with four standard poultry houses were selected in Alborz (n=6,250 birds per house) and Khorasan Razavi (n=8,000 birds per house) provinces of Iran. In each farm, the houses were randomly assigned to one of the four IBD intermediate vaccine brands including Dn, Vc, Ch, and Razi. The birds in Alborz were vaccinated against IBDV via drinking water at 18 and 22; and 15 and 21 days of age in Alborz and Khorasan Razavi flocks, respectively. The enzyme-linked immunosorbent assay antibody titers against IBDV were measured in 20 birds per group at 1, 28, 35, and 42 days of age. In addition, production attributes including body weight, feed conversion ratio, mortality, and production index were measured during the research period. According to the findings, the IBD antibody titers were not affected by the vaccine brands at 28, 35, and 42 days of age (P>0.05). Following the second IBD vaccination, an increasing trend in IBD antibody titers was noted in the Razi vaccine as well as other brands at days 35 and 42 compared to the previously recorded titers (p <0.05). Moreover, the production attributes of the flocks receiving various IBDV vaccine brands were not different (P>0.05). Regarding the productivity indices and high immunogenicity levels, the results indicated that the potential of the IBD Razi vaccine was comparable to the other investigated brands of commercial IBD vaccines, and nominated it as an immunogenic candidate vaccine for use in commercial broilers. | ||
| کلیدواژه‌ها | ||
| Antibody titer؛ Broiler؛ Immunity؛ Infectious bursal disease؛ Vaccination | ||
| عنوان مقاله [English] | ||
| مقایسه ایمنیزایی چهار واکسن اینترمدییت بیماری بورس عفونی در جوجههای گوشتی تجاری در ایران - مطالعه میدانی | ||
| چکیده [English] | ||
| بیماری بورس عفونی (infectious bursal disease: IBD) یک بیماری مسری با شیوع جهانی در جوجههای جوان است. واکسناسیون علیه IBD راهبرد اصلی پیشگیری و کنترل ویروس بیماری بورس عفونی است. هدف این مطالعه، مقایسه ایمنیزایی چهار واکسن تجاری بورس عفونی در جوجههای گوشتی (راس 308) پرورش یافته در مناطق دارای سابقه شیوع ویروس حاد بورس عفونی (vvIBDV) بود. دو مزرعه پرورشی جوجه گوشتی هر یک با چهار سالن پرورشی استاندارد در استانهای البرز (6250 پرنده در هر سالن) و خراسان رضوی (8000 پرنده در هر سالن) انتخاب شد. در هر مزرعه، سالنها به یکی از چهار برند واکسن اینترمدیت IBD شامل Dn، Vc، Ch و Razi اختصاص یافت. پرندهها به ترتیب در استانهای البرز و خراسان رضوی در روزهای 18 و 22، و 15 و 21، با روش آشامیدنی علیه IBD واکسینه شدند. تیتر آنتیبادی سرمی علیه IBDV (تعداد 20 پرنده در هر سالن پرورش) در سنین 1، 24 یا 28، 35 و 42 روزگی با روش الایزا اندازهگیری شد. افزون بر این، شاخصههای تولیدی شامل وزن بدن، ضریب تبدیل غذایی (FCR)، نرخ مرگومیر و شاخص تولید (PN) طی دورهی پرورش اندازهگیری شد. میانگین تیتر آنتیبادی علیه IBDV در زمانهای مختلف دورهی پرورش تحت تاثیر برند واکسن مورد استفاده قرار نگرفت (05/0<P). پس از تکرار واکسیناسیون، افزایش شایان توجهی در روند تیتر آنتیبادی علیه IBDV در پرندههای واکسینه شده با برند Razi و سایر برندها مشاهده شد (05/0>P). همچنین، شاخصههای تولیدی تحت تاثیر برندهای مختلف واکسن IBD قرار نگرفت (05/0<P). با توجه به شاخصههای تولیدی و سطح ایمنیزایی، نتایج این مطالعه، پتانسیل مشابه واکسن IBD تولیدی موسسه رازی را در مقایسه با سایر برندهای خارجی را نشان داد و آن را به عنوان یک واکسن ایمنوژنیک در جوجههای گوشتی تجاری معرفی نمود. | ||
| کلیدواژه‌ها [English] | ||
| تیتر آنتیبادی, جوجه گوشتی, بیماری بورس عفونی, مصونیت, واکسیناسیون | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
Berg, T.P., 2000. Acute infectious bursal disease in poultry: a review. Avian Pathol 29, 175-194.
Block, H., Meyer-Block, K., Rebeski, D.E., Scharr, H., de Wit, S., Rohn, K., et al., 2007. A field study on the significance of vaccination against infectious bursal disease virus (IBDV) at the optimal time point in broiler flocks with maternally derived IBDV antibodies. Avian Pathol 36, 401-409.
De Wit, J., 2001. Gumboro disease: estimation of optimal time of vaccination by the Deventer formula. Proceedings of the 3rd meeting of working group, Netherlands, pp. 21-28.
De Wit, J., 2003. Gumboro disease—the optimal time for vaccination. Int Poult Prod 11, 19-23.
Ebrahimi, M.M., Shahsavandi, S., Masoudi, S., 2009. Sequence analysis of VP2 gene of Infectious bursal disease viruses isolated from poultry in Iran., 16th World Veterinary Poultry Congress, Berlin.
Ebrahimi, M.M., Shahsavandi, S., Masoudi, S., Ghodsian, N., 2013. Isolation, characterization and standardization of new infectious Bursal disease virus for development of a live vaccine. Iran J Virol 4, 29-36.
Etteradossi, N., 2008. Infectious bursal disease (Gumboro disease). Office International des Epizooties., World Organization for Animal Health, Paris, France.
Jakka, P., Reddy, Y.K., Kirubaharan, J.J., Chandran, N.D., 2014. Evaluation of immune responses by live infectious bursal disease vaccines to avoid vaccination failures. Eur J Microbiol Immunol (Bp) 4, 123-127.
Kulikova, L., Jurajda, V., Juranová, R., 2004. Effects of infectious Bursal disease vaccination strains on the immune system in leghorn chickens. Acta Vet Brno 73, 205-209.
Lukert, P.D., Saif, Y.M., 2008. Infectious bursal disease. In: Calnek, B.W., Barnes, H.J., Beard, C.W., McDonald, L.R., Saif, Y.M. (Eds.), Diseases of poultry, Iowa State University Press, Ames, Mosby-Wolfe, London, pp. 721-738.
Mazariegos, L.A., Lukert, P.D., Brown, J., 1990. Pathogenicity and immunosuppressive properties of infectious bursal disease "intermediate" strains. Avian Dis 34, 203-208.
McFerran, J., 1993. Infectious bursal disease. In: McFerran, J.B. (Ed.), Virus infections of birds, Elsevier Science, Amsterdam, Netherlands, pp. 213-230.
Muller, H., Islam, M.R., Raue, R., 2003. Research on infectious bursal disease--the past, the present and the future. Vet Microbiol 97, 153-165.
Muller, H., Mundt, E., Eterradossi, N., Islam, M.R., 2012. Current status of vaccines against infectious bursal disease. Avian Pathol 41, 133-139.
Murphy, F.A., Gibbs, E.P.J., Horzinek, M.C., Studdert, M.J., 2000. Veterinary virology, Elsevier, New York.
Mymensingh, B., 2002. Effect of maternally derived antibody on vaccination against infectious bursal disease (Gumboro) with live vaccine in broiler. Int J Poultry Sci 1, 98-101.
Palya, V., 1991. Manual for the production of Marek's disease, Gumboro disease and inactivated Newcastle disease vaccines, Food and Agriculture Organization, Rome, Italy.
Rautenschlein, S., Kraemer, C., Vanmarcke, J., Montiel, E., 2005. Protective efficacy of intermediate and intermediate plus infectious bursal disease virus (IBDV) vaccines against very virulent IBDV in commercial broilers. Avian Dis 49, 231-237.
Rautenschlein, S., von Samson-Himmelstjerna, G., Haase, C., 2007. A comparison of immune responses to infection with virulent infectious bursal disease virus (IBDV) between specific-pathogen-free chickens infected at 12 and 28 days of age. Vet Immunol Immunopathol 115, 251-260.
Rautenschlein, S., Yeh, H.Y., Sharma, J.M., 2003. Comparative immunopathogenesis of mild, intermediate, and virulent strains of classic infectious bursal disease virus. Avian Dis 47, 66-78.
Shahsavandi, S., Ebrahimi, M.M., Sadeghi, K., Mahravani, H., 2014. Apoptotic response of chicken embryonic fibroblast cells to infectious bursal disease virus infections reflects viral pathogenicity. In Vitro Cell Dev Biol Anim 50, 858-864.
Smialek, M., Smialek, A., Koncicki, A., 2016. Practical aspects of estimation of optimal time for vaccination of chicken against IBD with use of "Deventer formula". Pol J Vet Sci 19, 425-427.
Smith, J., Sadeyen, J.R., Butter, C., Kaiser, P., Burt, D.W., 2015. Analysis of the early immune response to infection by infectious bursal disease virus in chickens differing in their resistance to the disease. J Virol 89, 2469-2482.
Tsukamoto, K., Tanimura, N., Kakita, S., Ota, K., Mase, M., Imai, K., et al., 1995. Efficacy of three live vaccines against highly virulent infectious bursal disease virus in chickens with or without maternal antibodies. Avian Dis 39, 218-229.
Zorman Rojs, O., Krapez, U., Slavec, B., Jursic-Cizerl, R., Poljanec, T., 2011. Field efficacy of different vaccines against infectious bursal disease in broiler flocks. Acta Vet Hung 59, 385-398. | ||
|
آمار تعداد مشاهده مقاله: 2,304 تعداد دریافت فایل اصل مقاله: 2,990 |
||
