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Comparison of the Immunogenicity of Four Infectious Bursal Disease Intermediate Vaccines in Commercial Broiler Flocks in Iran: A Field Trial Study | ||
| Archives of Razi Institute | ||
| مقاله 8، دوره 75، شماره 2، شهریور 2020، صفحه 205-212 اصل مقاله (431.79 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2019.124890.1292 | ||
| نویسندگان | ||
| M. M. Ebrahimi* 1؛ A. R. Yousefi2؛ Sh. Shahsavadi1؛ M. Zaghari3؛ M. R. Bassami4 | ||
| 1Department of Poultry Viral Vaccines Research and Production, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran | ||
| 2Department of Pathology and Experimental Animals, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran | ||
| 3Department of Animal Sciences, College of Agriculture and Natural Resource, University of Tehran, Karaj, Iran | ||
| 4Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran | ||
| چکیده | ||
| Infectious bursal disease (IBD) is a highly contagious disease in young chickens worldwide. The major strategy for the prevention and control of IBD virus (IBDV) is vaccination. Therefore, the present study aimed to compare the immunogenicity of four commercially available IBD vaccines on broilers (Ross 308) that were raised in areas with very virulent IBDV infection history. Two commercial broiler farms with four standard poultry houses were selected in Alborz (n=6,250 birds per house) and Khorasan Razavi (n=8,000 birds per house) provinces of Iran. In each farm, the houses were randomly assigned to one of the four IBD intermediate vaccine brands including Dn, Vc, Ch, and Razi. The birds in Alborz were vaccinated against IBDV via drinking water at 18 and 22; and 15 and 21 days of age in Alborz and Khorasan Razavi flocks, respectively. The enzyme-linked immunosorbent assay antibody titers against IBDV were measured in 20 birds per group at 1, 28, 35, and 42 days of age. In addition, production attributes including body weight, feed conversion ratio, mortality, and production index were measured during the research period. According to the findings, the IBD antibody titers were not affected by the vaccine brands at 28, 35, and 42 days of age (P>0.05). Following the second IBD vaccination, an increasing trend in IBD antibody titers was noted in the Razi vaccine as well as other brands at days 35 and 42 compared to the previously recorded titers (p <0.05). Moreover, the production attributes of the flocks receiving various IBDV vaccine brands were not different (P>0.05). Regarding the productivity indices and high immunogenicity levels, the results indicated that the potential of the IBD Razi vaccine was comparable to the other investigated brands of commercial IBD vaccines, and nominated it as an immunogenic candidate vaccine for use in commercial broilers. | ||
| کلیدواژهها | ||
| Antibody titer؛ Broiler؛ Immunity؛ Infectious bursal disease؛ Vaccination | ||
| عنوان مقاله [English] | ||
| مقایسه ایمنیزایی چهار واکسن اینترمدییت بیماری بورس عفونی در جوجههای گوشتی تجاری در ایران - مطالعه میدانی | ||
| چکیده [English] | ||
| بیماری بورس عفونی (infectious bursal disease: IBD) یک بیماری مسری با شیوع جهانی در جوجههای جوان است. واکسناسیون علیه IBD راهبرد اصلی پیشگیری و کنترل ویروس بیماری بورس عفونی است. هدف این مطالعه، مقایسه ایمنیزایی چهار واکسن تجاری بورس عفونی در جوجههای گوشتی (راس 308) پرورش یافته در مناطق دارای سابقه شیوع ویروس حاد بورس عفونی (vvIBDV) بود. دو مزرعه پرورشی جوجه گوشتی هر یک با چهار سالن پرورشی استاندارد در استانهای البرز (6250 پرنده در هر سالن) و خراسان رضوی (8000 پرنده در هر سالن) انتخاب شد. در هر مزرعه، سالنها به یکی از چهار برند واکسن اینترمدیت IBD شامل Dn، Vc، Ch و Razi اختصاص یافت. پرندهها به ترتیب در استانهای البرز و خراسان رضوی در روزهای 18 و 22، و 15 و 21، با روش آشامیدنی علیه IBD واکسینه شدند. تیتر آنتیبادی سرمی علیه IBDV (تعداد 20 پرنده در هر سالن پرورش) در سنین 1، 24 یا 28، 35 و 42 روزگی با روش الایزا اندازهگیری شد. افزون بر این، شاخصههای تولیدی شامل وزن بدن، ضریب تبدیل غذایی (FCR)، نرخ مرگومیر و شاخص تولید (PN) طی دورهی پرورش اندازهگیری شد. میانگین تیتر آنتیبادی علیه IBDV در زمانهای مختلف دورهی پرورش تحت تاثیر برند واکسن مورد استفاده قرار نگرفت (05/0<P). پس از تکرار واکسیناسیون، افزایش شایان توجهی در روند تیتر آنتیبادی علیه IBDV در پرندههای واکسینه شده با برند Razi و سایر برندها مشاهده شد (05/0>P). همچنین، شاخصههای تولیدی تحت تاثیر برندهای مختلف واکسن IBD قرار نگرفت (05/0<P). با توجه به شاخصههای تولیدی و سطح ایمنیزایی، نتایج این مطالعه، پتانسیل مشابه واکسن IBD تولیدی موسسه رازی را در مقایسه با سایر برندهای خارجی را نشان داد و آن را به عنوان یک واکسن ایمنوژنیک در جوجههای گوشتی تجاری معرفی نمود. | ||
| کلیدواژهها [English] | ||
| تیتر آنتیبادی, جوجه گوشتی, بیماری بورس عفونی, مصونیت, واکسیناسیون | ||
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| مراجع | ||
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