| تعداد نشریات | 284 |
| تعداد نشریات سازمان | 82 |
| تعداد شماره‌ها | 3,083 |
| تعداد مقالات | 34,401 |
| تعداد مشاهده مقاله | 48,309,052 |
| تعداد دریافت فایل اصل مقاله | 79,022,359 |
Effect of Oat (Avena Sativa L.) Extract on Experimental Sciatic Nerve Injury in Rats | ||
| Archives of Razi Institute | ||
| مقاله 14، دوره 75، شماره 2، شهریور 2020، صفحه 249-256 اصل مقاله (1.27 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2019.124805.1288 | ||
| نویسندگان | ||
| Z. Darzian Rostami1؛ A. Asghari* 1؛ A. Jahandideh1؛ P. Mortazavi2؛ A. Akbarzadeh3، 4 | ||
| 1Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 4Universal Scientific Education and Research Network, Tabriz, Iran | ||
| چکیده | ||
| Peripheral nerve disorders are the most common neurological problems; therefore, it is important to intervene to treat or stop the resulting side effects. This study aimed to investigate the effect of oat extract on experimental sciatic nerve injury in rats. Totally, 50 adult male rats were divided into five groups (n=10). Group 1 was exposed to sham condition, and group 2 was regarded as the control group (nerve injury without treatment). Moreover, groups 3-5 were subjected to sciatic nerve injury, and they received oral gavages of the oat extract (100, 200, and 400 mg/kg), respectively. Subsequently, 2 and 4 weeks later, the rats were euthanized for pathological evaluation of nerve repair. The results showed an increase in the formation of the perineurium and epineurium dose in the oat-treated groups (100, 200, and 400 mg/kg), compared to the control group after 2 weeks (p <0.05). Furthermore, the presence of inflammatory cells in the oat extract-treated groups (100, 200, and 400 mg/kg) decreased, compared to that in the control group after 2 weeks (p <0.05). In addition, the swelling of the axon significantly decreased in the oat extract-treated groups (200 and 400 mg/kg), compared to the control group (p <0.05). However, the axon dose-dependently increased in oat-treated groups (100, 200, and 400 mg/kg), compared to that in the control group after 4 weeks (p <0.05). These results suggest that oat extract has positive effects on sciatic nerve repair in rats. | ||
| کلیدواژه‌ها | ||
| Oat extract؛ Rat؛ Sciatic nerve injury | ||
| عنوان مقاله [English] | ||
| تاثیر عصاره جو دوسر (Avana sativa L) بر روی آسیب تجربی عصب سیاتیک در موش صحرایی | ||
| چکیده [English] | ||
| اختلالات اعصاب محیطی جز شایعترین مشکلات عصبی هستند که مداخله برای درمان و یا متوقف کردن عوارض ناشی از آن مهم است. هدف از این مطالعه تعیین تاثیر عصاره جو دوسر بر روی آسیب تجربی عصب سیاتیک در موش صحرایی بود. پنجاه موش صحرایی نر بالغ به پنج گروه تقسیم شدند (n=10). گروه 1 به عنوان گروه شاهد، گروه 2 گروه کنترل (آسیب عصب بدون درمان) نگهداری شد. در گروه های آسیب دیده عصب سیاتیک به ترتیب 3-5، پس از آن حیوانات به صورت خوراکی عصاره جو دوسر (به ترتیب 100، 200 و 400 میلی گرم بر کیلوگرم) دریافت کردند. سپس 2 و 4 هفته بعد، برای بررسی ارزیابی پاتولوژیک ترمیم عصب، موشها از بین رفتند. تشکیل پرینوریوم و اپینوریم به صورت وابسته به دوز در گروههای تحت درمان با عصاره جو دوسر (100، 200 و 400 میلی گرم بر کیلوگرم) در مقایسه با گروه کنترل پس از 2 هفته افزایش یافت (P <0.05). حضور سلولهای التهابی در گروههای تحت درمان با عصاره جو (100، 200 و 400 میلی گرم بر کیلوگرم) در مقایسه با گروه کنترل بعد از 2 هفته کاهش یافت (P <0.05). تورم اکسون به طور معنی داری در گروه های تحت درمان با عصاره جو دوسر (200 و 400 میلی گرم بر کیلوگرم) در مقایسه با گروه کنترل کاهش یافت (P <0.05). تعداد آکسون به طور معنی داری در گروه تحت درمان با عصاره جو دوسر (100، 200 و 400 میلی گرم در کیلوگرم) در مقایسه با گروه کنترل بعد از 4 هفته افزایش یافت (P <0.05). نتایج نشان داد که عصاره جو دوسر اثر مثبتی بر روی ترمیم عصب سیاتیک در موش صحرایی دارد. | ||
| کلیدواژه‌ها [English] | ||
| عصاره جو, آسیب عصب سیاتیک, موش صحرایی | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
Akkol, E.K., Süntar, I., Orhan, I.E., Keles, H., Kan, A., Çoksari, G., 2011. Assessment of dermal wound healing and in vitro antioxidant properties of Avena sativa L. J Cereal Sci 53, 285-290.
Aktas-Akyildiz, E., Sibakov, J., Nappa, M., Hytönen, E., Koksel, H., Poutanen, K., 2018. Extraction of soluble β-glucan from oat and barley fractions: Process efficiency and dispersion stability. J Cereal Sci 81, 60-68.
Alexandrescu, D.T., Vaillant, J.G., Dasanu, C.A., 2007. Effect of treatment with a colloidal oatmeal lotion on the acneform eruption induced by epidermal growth factor receptor and multiple tyrosine-kinase inhibitors. Clin Exp Dermatol 32, 71-74.
Allan, G.L., Parkinson, S., Booth, M.A., Stone, D.A., Rowland, S.J., Frances, J., et al., 2000. Replacement of fish meal in diets for Australian silver perch, Bidyanus bidyanus: I. Digestibility of alternative ingredients. Aquaculture 186, 293-310.
Asghari, A., Akbari, G., Meghdadi, A., Mortazavi, P., 2016. Protective effect of metformin on testicular ischemia/reperfusion injury in rats. Acta Cir Bras 31, 411-416.
Ben Halima, N., Ben Saad, R., Khemakhem, B., Fendri, I., Abdelkafi, S., 2015. Oat (Avena sativa L.): Oil and Nutriment Compounds Valorization for Potential Use in Industrial Applications. J Oleo Sci 64, 915-932.
Berry, N.M., Robinson, M.J., Bryan, J., Buckley, J.D., Murphy, K.J., Howe, P.R., 2011. Acute effects of an Avena sativa herb extract on responses to the Stroop Color-Word test. J Altern Complement Med 17, 635-637.
Caner, B., Kafa, M.I., Bekar, A., Kurt, M.A., Karli, N., Cansev, M., et al., 2012. Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury. Neurol Res 34, 238-245.
Chen, C.Y., Milbury, P.E., Collins, F.W., Blumberg, J.B., 2007. Avenanthramides are bioavailable and have antioxidant activity in humans after acute consumption of an enriched mixture from oats. J Nutr 137, 1375-1382.
Feng, B., Ma, L.J., Yao, J.J., Fang, Y., Mei, Y.A., Wei, S.M., 2013. Protective effect of oat bran extracts on human dermal fibroblast injury induced by hydrogen peroxide. J Zhejiang Univ Sci B 14, 97-105.
Feng, X., Yuan, W., 2015. Dexamethasone enhanced functional recovery after sciatic nerve crush injury in rats. Biomed Res Int 2015, 627923.
Grunden, A.M., Sederoff, H., Smith, C.M., Aslett, L.D., 2018. Methods and compositions for enhanced biomass production and increased abiotic stress tolerance, North Carolina State University, North Carolina.
Guven, M., Golge, U.H., Aslan, E., Sehitoglu, M.H., Aras, A.B., Akman, T., et al., 2016. The effect of aloe vera on ischemia--Reperfusion injury of sciatic nerve in rats. Biomed Pharmacother 79, 201-207.
He, B., Bai, Y., Jiang, L., Wang, W., Li, T., Liu, P., et al., 2018. Effects of Oat Bran on Nutrient Digestibility, Intestinal Microbiota, and Inflammatory Responses in the Hindgut of Growing Pigs. Int J Mol Sci 19, 2407.
Ji, L.L., Lay, D., Chung, E., Fu, Y., Peterson, D.M., 2003. Effects of avenanthramides on oxidant generation and antioxidant enzyme activity in exercised rats. Nutr Res 23, 1579-1590.
Jiang, X., Ma, J., Wei, Q., Feng, X., Qiao, L., Liu, L., et al., 2016. Effect of Frankincense Extract on Nerve Recovery in the Rat Sciatic Nerve Damage Model. Evid Based Complement Alternat Med 2016, 3617216.
Kandhare, A.D., Mukherjee, A.A., Bodhankar, S.L., 2017. Neuroprotective effect of Azadirachta indica standardized extract in partial sciatic nerve injury in rats: Evidence from anti-inflammatory, antioxidant and anti-apoptotic studies. Excli J 16, 546-565.
Koksal, M., Oguz, E., Baba, F., Eren, M.A., Ciftci, H., Demir, M.E., et al., 2012. Effects of melatonin on testis histology, oxidative stress and spermatogenesis after experimental testis ischemia-reperfusion in rats. Eur Rev Med Pharmacol Sci 16, 582-588.
Kulbacka, J., Saczko, J., Chwilkowska, A., 2009. [Oxidative stress in cells damage processes]. Pol Merkur Lekarski 27, 44-47.
Lanza, C., Raimondo, S., Vergani, L., Catena, N., Senes, F., Tos, P., et al., 2012. Expression of antioxidant molecules after peripheral nerve injury and regeneration. J Neurosci Res 90, 842-848.
Liu, B., Yang, T., Luo, Y., Zeng, L., Shi, L., Wei, C., et al., 2018. Oat β-glucan inhibits adipogenesis and hepatic steatosis in high fat diet-induced hyperlipidemic mice via AMPK signaling. J Functional Foods 41, 72-82.
Ma, J., Yu, H., Liu, J., Chen, Y., Wang, Q., Xiang, L., 2016. Curcumin promotes nerve regeneration and functional recovery after sciatic nerve crush injury in diabetic rats. Neurosci Lett 610, 139-143.
Mecocci, P., Boccardi, V., Cecchetti, R., Bastiani, P., Scamosci, M., Ruggiero, C., et al., 2018. A Long Journey into Aging, Brain Aging, and Alzheimer's Disease Following the Oxidative Stress Tracks. J Alzheimers Dis 62, 1319-1335.
Meydani, M., 2009. Potential health benefits of avenanthramides of oats. Nutr Rev 67, 731-735.
Mir, S.M., Sahu, B.D., Koneru, M., Kuncha, M., Jerald, M.K., Ravuri, H.G., et al., 2018. Supplementation of oat (Avena sativa L.) extract abates alcohol-induced acute liver injury in a mouse model. Nutr Res 54, 80-92.
Mizuno, A., 2005. Clinical evaluation of A-Derma Exomega Cream for atopic dry skin. Skin Res 4, 581-587.
Moccetti, T., Wullschleger, C., Schmidt, A., Aydogan, C., Kreuter, M., 2006. Bioactivity-based development of a wild green oat (Avena sativa L.) extract in support of mental health disorders. Zeitschrift Phytother 27, P24.
O'Moore, K.M., Vanlandschoot, C.M., Dickman, J.R., Figi, A.R., Rothert, A.M., Ji, L.L., 2005. Effect Of Avenathramide On Rat Skeletal Muscle Injury Induced By Lengthening Contraction: 2435 1: 45 PM–2: 00 PM. Med Sci Sports Exer 37, S466.
Sandhu, K.S., Godara, P., Kaur, M., Punia, S., 2017. Effect of toasting on physical, functional and antioxidant properties of flour from oat (Avena sativa L.) cultivars. J Saudi Soci Agric Sci 16, 197-203.
Senger, J.L.B., Verge, V.M.K., Macandili, H.S.J., Olson, J.L., Chan, K.M., Webber, C.A., 2018. Electrical stimulation as a conditioning strategy for promoting and accelerating peripheral nerve regeneration. Exp Neurol 302, 75-84.
Sriraksa, N., Kongsui, R., Thongrong, S., Duangjai, A., Hawiset, T., 2019. Effect of Azadirachta indica flower extract on functional recovery of sciatic nerve crush injury in rat models of DM. Exp Ther Med 17, 541-550.
Tuglu, D., Yuvanc, E., Yilmaz, E., Gencay, I.Y., Atasoy, P., Kisa, U., et al., 2015. The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury. Acta Cir Bras 30, 414-421.
Veerasubramanian, P.K., Thangavel, P., Kannan, R., Chakraborty, S., Ramachandran, B., Suguna, L., et al., 2018. An investigation of konjac glucomannan-keratin hydrogel scaffold loaded with Avena sativa extracts for diabetic wound healing. Colloids Surf B Biointerfaces 165, 92-102.
Yulug, E., Turedi, S., Alver, A., Turedi, S., Kahraman, C., 2013. Effects of resveratrol on methotrexate-induced testicular damage in rats. Sci World J 2013, 489659.
Zhao, L., Cui, S., 2016. Curcumin improves sciatic nerve regeneration by up-regulating S100 expression in mice. Biomed Res 27, 322-327.
Zimmermann, M., 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16, 109-110. | ||
|
آمار تعداد مشاهده مقاله: 2,356 تعداد دریافت فایل اصل مقاله: 2,913 |
||
