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Effect of Oat (Avena Sativa L.) Extract on Experimental Sciatic Nerve Injury in Rats | ||
| Archives of Razi Institute | ||
| مقاله 14، دوره 75، شماره 2، شهریور 2020، صفحه 249-256 اصل مقاله (1.27 M) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2019.124805.1288 | ||
| نویسندگان | ||
| Z. Darzian Rostami1؛ A. Asghari* 1؛ A. Jahandideh1؛ P. Mortazavi2؛ A. Akbarzadeh3، 4 | ||
| 1Department of Clinical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 4Universal Scientific Education and Research Network, Tabriz, Iran | ||
| چکیده | ||
| Peripheral nerve disorders are the most common neurological problems; therefore, it is important to intervene to treat or stop the resulting side effects. This study aimed to investigate the effect of oat extract on experimental sciatic nerve injury in rats. Totally, 50 adult male rats were divided into five groups (n=10). Group 1 was exposed to sham condition, and group 2 was regarded as the control group (nerve injury without treatment). Moreover, groups 3-5 were subjected to sciatic nerve injury, and they received oral gavages of the oat extract (100, 200, and 400 mg/kg), respectively. Subsequently, 2 and 4 weeks later, the rats were euthanized for pathological evaluation of nerve repair. The results showed an increase in the formation of the perineurium and epineurium dose in the oat-treated groups (100, 200, and 400 mg/kg), compared to the control group after 2 weeks (p <0.05). Furthermore, the presence of inflammatory cells in the oat extract-treated groups (100, 200, and 400 mg/kg) decreased, compared to that in the control group after 2 weeks (p <0.05). In addition, the swelling of the axon significantly decreased in the oat extract-treated groups (200 and 400 mg/kg), compared to the control group (p <0.05). However, the axon dose-dependently increased in oat-treated groups (100, 200, and 400 mg/kg), compared to that in the control group after 4 weeks (p <0.05). These results suggest that oat extract has positive effects on sciatic nerve repair in rats. | ||
| کلیدواژه‌ها | ||
| Oat extract؛ Rat؛ Sciatic nerve injury | ||
| عنوان مقاله [English] | ||
| تاثیر عصاره جو دوسر (Avana sativa L) بر روی آسیب تجربی عصب سیاتیک در موش صحرایی | ||
| چکیده [English] | ||
| اختلالات اعصاب محیطی جز شایعترین مشکلات عصبی هستند که مداخله برای درمان و یا متوقف کردن عوارض ناشی از آن مهم است. هدف از این مطالعه تعیین تاثیر عصاره جو دوسر بر روی آسیب تجربی عصب سیاتیک در موش صحرایی بود. پنجاه موش صحرایی نر بالغ به پنج گروه تقسیم شدند (n=10). گروه 1 به عنوان گروه شاهد، گروه 2 گروه کنترل (آسیب عصب بدون درمان) نگهداری شد. در گروه های آسیب دیده عصب سیاتیک به ترتیب 3-5، پس از آن حیوانات به صورت خوراکی عصاره جو دوسر (به ترتیب 100، 200 و 400 میلی گرم بر کیلوگرم) دریافت کردند. سپس 2 و 4 هفته بعد، برای بررسی ارزیابی پاتولوژیک ترمیم عصب، موشها از بین رفتند. تشکیل پرینوریوم و اپینوریم به صورت وابسته به دوز در گروههای تحت درمان با عصاره جو دوسر (100، 200 و 400 میلی گرم بر کیلوگرم) در مقایسه با گروه کنترل پس از 2 هفته افزایش یافت (P <0.05). حضور سلولهای التهابی در گروههای تحت درمان با عصاره جو (100، 200 و 400 میلی گرم بر کیلوگرم) در مقایسه با گروه کنترل بعد از 2 هفته کاهش یافت (P <0.05). تورم اکسون به طور معنی داری در گروه های تحت درمان با عصاره جو دوسر (200 و 400 میلی گرم بر کیلوگرم) در مقایسه با گروه کنترل کاهش یافت (P <0.05). تعداد آکسون به طور معنی داری در گروه تحت درمان با عصاره جو دوسر (100، 200 و 400 میلی گرم در کیلوگرم) در مقایسه با گروه کنترل بعد از 4 هفته افزایش یافت (P <0.05). نتایج نشان داد که عصاره جو دوسر اثر مثبتی بر روی ترمیم عصب سیاتیک در موش صحرایی دارد. | ||
| کلیدواژه‌ها [English] | ||
| عصاره جو, آسیب عصب سیاتیک, موش صحرایی | ||
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