اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها3,024
تعداد مقالات33,786
تعداد مشاهده مقاله45,140,982
تعداد دریافت فایل اصل مقاله55,706,781
Rezaei, Minoo, Mashinchian Moradi, Ali, Mortazavi, Pejman, Jamili, Shahla. (1398). Effects of chronic exposure to carbamazepine on hematological parameters in Cyprinus carpio. سامانه مدیریت نشریات علمی, 19(1), 443-456. doi: 10.22092/ijfs.2019.119014
Minoo Rezaei; Ali Mashinchian Moradi; Pejman Mortazavi; Shahla Jamili. "Effects of chronic exposure to carbamazepine on hematological parameters in Cyprinus carpio". سامانه مدیریت نشریات علمی, 19, 1, 1398, 443-456. doi: 10.22092/ijfs.2019.119014
Rezaei, Minoo, Mashinchian Moradi, Ali, Mortazavi, Pejman, Jamili, Shahla. (1398). 'Effects of chronic exposure to carbamazepine on hematological parameters in Cyprinus carpio', سامانه مدیریت نشریات علمی, 19(1), pp. 443-456. doi: 10.22092/ijfs.2019.119014
Rezaei, Minoo, Mashinchian Moradi, Ali, Mortazavi, Pejman, Jamili, Shahla. Effects of chronic exposure to carbamazepine on hematological parameters in Cyprinus carpio. سامانه مدیریت نشریات علمی, 1398; 19(1): 443-456. doi: 10.22092/ijfs.2019.119014

Effects of chronic exposure to carbamazepine on hematological parameters in Cyprinus carpio

Iranian Journal of Fisheries Sciences
مقاله 198، دوره 19، شماره 1، فروردین 2020، صفحه 443-456    اصل مقاله (481.24 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22092/ijfs.2019.119014
نویسندگان
Minoo Rezaei1؛ Ali Mashinchian Moradi* 1؛ Pejman Mortazavi2؛ Shahla Jamili1
1Department of Marine Biology, Science and Research Branch, Islamic Azad University
2Department of Pathology, Science and Research Branch, Islamic Azad University
چکیده
Tests on pysicochemical parameters in the recent years have confirmed the existence of drug residues and their metabolites in different parts of aquatic environments the permanent release of which has led to micro-persistent pollution. The drugs are designed in a way to be chemically stable, resistant to degradation and to survive by using their biological effects on the organisms. In the present research study, toxicity and the effect of carbamazepine on Cyprinus carpio was examined using blood responses. Thus, the effects of three different concentrations of carbamazepine (1.25, 2.5 and 5 mg L-1) on the changes of blood factors such as red blood cell (RBC), hemoglobin (Hb), hematocrit (Hct), mean cellular volume (MCV), mean cellular hemoglobin (MCH), mean cellular hemoglobin concentration (MCHC), white blood cell (WBC), lymphocyte (Lymph), neutrophil (Neut) and monocyte (Mono) were studied on blood samples collected on days 7, 14 and 21 after exposure to the drug. The results showed that RBC, WBC and lymph counts were reduced in fishes treated with carbamazepine (CBZ). In contrast, the value of Hb, Hct, MCV, MCH, Neut and Mono were increased after exposure to carbamazepine. No significant difference was observed in the MCHC levels in all concentrations. Changes in hematological parameters can act as a biomarker in testing the toxicity of CBZ in aquatic environments. However, detailed studies regarding the application of special biomarkers for assessing human drugs is required.
 
کلیدواژه‌ها
Carbamazepine؛ Hematological parameters؛ Cyprinus carpio
آمار
تعداد مشاهده مقاله: 2,098
تعداد دریافت فایل اصل مقاله: 476


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب