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Akbary, P, Mirvaghefi, A, Akhlaghi, M, Majazi Amiri, B. (1393). Effects of letrozole, non-steroidal aromatase inhibitor, on serum sex steroid levels, oocyte diameter and gonadosomatic index (GSI) in rainbow trout (Oncorhynchus mykiss). سامانه مدیریت نشریات علمی, 14(1), 289-301. doi: 10.22092/ijfs.2018.114440
P Akbary; A Mirvaghefi; M Akhlaghi; B Majazi Amiri. "Effects of letrozole, non-steroidal aromatase inhibitor, on serum sex steroid levels, oocyte diameter and gonadosomatic index (GSI) in rainbow trout (Oncorhynchus mykiss)". سامانه مدیریت نشریات علمی, 14, 1, 1393, 289-301. doi: 10.22092/ijfs.2018.114440
Akbary, P, Mirvaghefi, A, Akhlaghi, M, Majazi Amiri, B. (1393). 'Effects of letrozole, non-steroidal aromatase inhibitor, on serum sex steroid levels, oocyte diameter and gonadosomatic index (GSI) in rainbow trout (Oncorhynchus mykiss)', سامانه مدیریت نشریات علمی, 14(1), pp. 289-301. doi: 10.22092/ijfs.2018.114440
Akbary, P, Mirvaghefi, A, Akhlaghi, M, Majazi Amiri, B. Effects of letrozole, non-steroidal aromatase inhibitor, on serum sex steroid levels, oocyte diameter and gonadosomatic index (GSI) in rainbow trout (Oncorhynchus mykiss). سامانه مدیریت نشریات علمی, 1393; 14(1): 289-301. doi: 10.22092/ijfs.2018.114440

Effects of letrozole, non-steroidal aromatase inhibitor, on serum sex steroid levels, oocyte diameter and gonadosomatic index (GSI) in rainbow trout (Oncorhynchus mykiss)

Iranian Journal of Fisheries Sciences
مقاله 22، دوره 14، شماره 1، فروردین 2015، صفحه 289-301    اصل مقاله (296.3 K)
شناسه دیجیتال (DOI): 10.22092/ijfs.2018.114440
نویسندگان
P Akbary* ؛ A Mirvaghefi؛ M Akhlaghi؛ B Majazi Amiri
چکیده
The objective of this study was to contribute to investigate the efficacy of letrozole, a potent non-steroidal aromatase inhibitor, on serum sex steroid levels and oocyte growth in rainbow trout females. Serum steroid levels were measured using an indirect enzyme-linked immunosorbent assay (ELISA) before and 22 days after an initial injection with 1, 2.5 mg kg-1 and subsequent weekly injection with 2.5 mg kg-1letrozole. After the last blood collection, gonad tissues were removed and oocyte diameter and GSI were determined. In all groups treated with letrozole, serum 17β- esteradiol levels (E2) decreased significantly and inversely serum 17α-20ß dihydroxy-4 pregnen- 3- one (17α-20ß-P), testosterone(T) levels increased significantly from 6 to 96 h after injection (p < 0.05). The lowest E2 levels, oocyte diameter and GSI were measured in the group treated weekly with 2.5 mg kg-1 letrozole (p < 0.05). This study demonstrates that letrozole has the potential to interfere in the synthesis of endogenous estrogens from androgens and delay gonadal development.
کلیدواژه‌ها
Aromatase inhibitor؛ Sex steroid؛ GSI؛ Oncorhynchus mykiss
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تعداد مشاهده مقاله: 130
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