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Taherkhani, Mahboubeh. (1394). Total Phenolic Content, Antioxidant Activity and In vitro Cytotoxicity of the Essential Oil of Jurinea leptoloba DC.. سامانه مدیریت نشریات علمی, 4(2), 171-178. doi: 10.22092/jmpb.2015.108905
Mahboubeh Taherkhani. "Total Phenolic Content, Antioxidant Activity and In vitro Cytotoxicity of the Essential Oil of Jurinea leptoloba DC.". سامانه مدیریت نشریات علمی, 4, 2, 1394, 171-178. doi: 10.22092/jmpb.2015.108905
Taherkhani, Mahboubeh. (1394). 'Total Phenolic Content, Antioxidant Activity and In vitro Cytotoxicity of the Essential Oil of Jurinea leptoloba DC.', سامانه مدیریت نشریات علمی, 4(2), pp. 171-178. doi: 10.22092/jmpb.2015.108905
Taherkhani, Mahboubeh. Total Phenolic Content, Antioxidant Activity and In vitro Cytotoxicity of the Essential Oil of Jurinea leptoloba DC.. سامانه مدیریت نشریات علمی, 1394; 4(2): 171-178. doi: 10.22092/jmpb.2015.108905

Total Phenolic Content, Antioxidant Activity and In vitro Cytotoxicity of the Essential Oil of Jurinea leptoloba DC.

Journal of Medicinal plants and By-Products
مقاله 6، دوره 4، شماره 2، آذر 2015، صفحه 171-178    اصل مقاله (248.28 K)
شناسه دیجیتال (DOI): 10.22092/jmpb.2015.108905
نویسنده
Mahboubeh Taherkhani*
Department of Chemistry, College of Science, Takestan Branch, Islamic Azad University, Takestan, Iran
چکیده
The essential oil from the aerial parts ofJurinea leptoloba DC., collected from Shiraz (South of Iran), was investigated for total phenolic content (TPC), antioxidant and cytotoxic effects. TPC of J. leptoloba oil was determined to be 16.53 ± 5.69 μg gallic acid equivalent/mg sample (μg GAE/mg oil) using the Folin-Ciocalteau assay. The ferric reducing power of the oil was determined 0.117 ± 0.01 GAE (mg/g).J. leptoloba oil exhibited a dose-dependent scavenging of DPPH, with an IC50 value of 24.50 mg/ml. Antioxidant activity percentage of the essential oil of J. leptoloba determined by β-carotene bleaching test revealed less potential than both standards BHT and BHA (62.01 ± 2.45%, 2.5 mg/ml oil). Cytotoxicity was measured using a modified MTT assay. IC50 valuesforHeLa and lymphocyte cells were calculated to be 290.76 and 2900.97 µg/ml, respectively. The results suggest application of J. leptoloba essentialoil as a moderate antioxidant and anticancer agent.
کلیدواژه‌ها
Jurinea leptoloba؛ Total phenolic content؛ Antioxidant activity؛ Cytotoxicity
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