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| تعداد نشریات | 286 |
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Protective Effect of Salvia officinalis on Testes Tissue Damages of Rats Intoxicated by Diazinon | ||
| Journal of Medicinal plants and By-products | ||
| مقاله 6، دوره 4، شماره 1، تیر 2015، صفحه 39-43 اصل مقاله (243.34 K) | ||
| شناسه دیجیتال (DOI): 10.22092/jmpb.2015.108889 | ||
| نویسندگان | ||
| Esmail Fattahi* 1؛ Mojtaba Vaseghi2 | ||
| 1Department of Biology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran | ||
| 2Department of Physical Science Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran | ||
| چکیده | ||
| Diazinon is an organophosphate which exerts tissue damages by generating free radicals thereby inducing oxidative stress. The purpose of this study is to determine the protective effect of Salvia officinalis L.extract on testes of rats intoxicated by diazinon. In this experimental study, 45 mature male rats were equally divided into three groups of Control (C), Diazinon (DZN) and Diazinon-Extract (DZN-E). The D-E group received a one-time 200 mg/Kg diazinon for the entire period of study and the S. officinalis extract for four weeks (5 days a week) via intraperitoneal injection. The animals were sacrificed 24 hours later. Tissue sections were prepared and subjected to microscopic examination. The collected data were statistically analyzed using one way-ANOVA. number of spermatogonia, spermatocytes, spermatids as well as the diameter of seminiferous tubule have been significantly reduced in DZN group compared to those in C group (P<0.05). However compared to the DZN group, the DZN-E group showed increase in the number of the cell types under study and the diameter of seminiferous tubule and these increases were statistically significant (P<0.05). Our results indicate that S. officinalis extract minimizes diazinon-mediated tissue damages on testes probably by scavenging free radicals and so reducing toxicity caused due to oxidative stress. | ||
| کلیدواژه‌ها | ||
| Salvia officinalis؛ DIAZINON؛ Testes؛ Spermatogonia | ||
| مراجع | ||
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1. Katzung BG. Basic and Clinical pharmacology. 10th. London: Simon & Schuster, 2005, pp. 948
2. Hsieh BH, Deng JF, Ger J, Tsai WJ. Acetylcholinesterase inhibition and the extrapyramidal syndrome: a review of the neurotoxicity of organophosphate. Neurotoxicology. 2001; 22:423-7.
3. Oliveira-Silva JJ, Alves SR, Meyer A, Perez F, Sarcinelli PN, da Costa Mattos RC, Moreira JC. [Influence of socioeconomic factors on the pesticides poisoning, Brazil]. Rev SaudePublica. 2001;35:130-5. (Article in Portuguese)
4. Schroeder JC. Metabolic susceptibility to agricultural pesticides and non-Hodgkin's lymphoma.Scand J Work Environ Health.2005;31:26-32.
5. Kamrin MA. Pesticide profiles: toxicity, environmental impact and fate. 7th. Boca Raton: Lewis Publishers. 1997, pp. 157-9.
6. Dahlgren JG, Takhar HS, Ruffalo CA, Zwass M. Health effects of diazinon on a family. J Toxicol. Clin. Toxicol. 2004;42:579- 91.
7. Fattahi E, Parivar K, JorsaraeiSGhA, Moghadamnia AA. The effects of diazinon on testosterone, FSH and LH levels and testicular tissue in mice. Iran J Reprod Med. 2009;7:59-64.
8. Blanco-Muٌoz J, Morales MM, Lacasaٌa M, Aguilar-Garduٌo C, Bassol S, Cebriلn ME. Exposure to organophosphate pesticides and male hormone profile in floriculturist of the state of Morelos, Mexico. Hum Reprod. 2010;25:1787-95.
9. Yucra S, Rubio J, Gasco M, Gonzales C, Steenland K, Gonzales GF. Semen quality and reproductive sex hormone levels in Peruvian pesticide sprayers.Int J Occup Environ Health. 2006;12:355-61.
10. Fattahi E, Jorsaraei SGA, Gardaneh M. The effects of carbaryl on the pituitary-gonad axis in male rats. Iran J Reprod Med. 2012;10:419-424.
11. Fattahy E, Jorsaraei SGA, Parivar K, Moghaddamnia AA. Influence of Diazinon on spermatogenesis in mice. Koomesh J. 2007; 9:75-82. (in Persian)
12. Fattahi E, Jorsaraei SGA, Parivar K, Moghaddamnia AA. The effects of a single dosage of Diazinon and Hinosan on the structureof testis tissue and sexual hormones in Mice. Cell J. 2010;12:405-10. (in Persian)
13. Kurodak K, Yamaguchy Y, Endo G. Mitotic toxicity,sister chromatid exchange, and rec assay of pesticides. Arch Environ ContamToxicol. 1992;23:13-18.
14. Evenson D, Jost L. Sperm chromatin structure assay for fertility assessment. CurrProtocCytom. chapter : Unit. 2001; pp:7.13.
15. Rush T, Liu XQ, Hjelmhaug J, Lobner D. Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture. Neuroscience. 2010; 166:899-906.
16. Yu F, Wang Z, Ju B, Wang Y, Wang J, Bai D. Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamins C and E. ExpToxicolPathol. 2008 ;59:415-23.
17. Fallah-mohammadi Z, Hajizadeh-Moghaddam A, Aghasi M, Esmaeili AH. Neuroprotective effects of voluntary exercise and hydroalcoholic extraction of Eriobotrya Japonica on dopamine and tyrosine hydroxylase in the striatum of parkinsonian rats. Koomesh J. 2013;15:31-38(in Persian)
18. Osawa T, Kato Y. Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia. Ann. NY. Acad. Sci. 2007;1043:440-451.
19. Durling NE, Catchpole OJ, Grey JB, Webby RF, Mitchell KA, Foo LY, et al. Extraction of phenolics and essential oil from dried sage (Salvia officinalis) using ethanol-water mixtures. Food Chem. 2007;101:1417-24.
20. Yinrong L, Yeap F. Antioxidant activities of polyphenols from sage (Salvia officinalis). Food Chem 2001;75:197-202.
21. Ames BM, Shigena MK, Hagen TM. Oxidants, antioxidants and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 1993;90:7915-7922.
22. Stadtman ER. Protein oxidation and aging. Science. 1992;57:1220-1224.
23- Esmaeili MA, Sonboli A, Kanani MR, Sadeghi H. Salvia sahendica prevents tissue damages induced by alcohol in oxidative stress conditions: Effect on liver and kidney oxidative parameters. J. Med. Plant Res. 2009; 3:276-283.
24. Contreras HR, Bustos Obregon E. Morphological alterations in mouse testis by single dose of malathion. J ExpZool. 1999; 284:355-9.
25-Altuntas I, Kilinc I, Orhan H, Demirel R, Koylu H, Delibas N. The effects of diazinon on lipid peroxidation and antioxidant enzymes in erythrocytes in vitro. Hum Exp Toxicol. 2004; 23:9-13.
26- Siesh H, Stanl W. Vitamin E and C.Betacarotene and other Carotenoids as antioxidants. Am J Clin Nutr. 1995; 82:1315-1321.
27. Halliwell B, Gutteridge JM. Role of free-radicals and catalitic metal ions in human disease: an overview. Methods Enzymol. 1990; 186: 1-85.
28. Osawa T, Kato Y. Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia. Ann N Y Acad Sci. 2007;1043:440-451.
29. Hohmann J, Zupkó I, Rédei D, Csányi M, Falkay G, Máthé I, Janicsák G. Protective effects of the aerial parts of Salvia officinalis, Melissa Officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation. Planta Med. 1999; 656:576-8. 30. Zupkó I, Hohmann J, Rédei D, Falkay G, Janicsák G, Máthé I. Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme-independent systems of lipid peroxidation and their phenolic constituents. Planta Med. 2001;674:366-8. 31. Miroslav R, Jana T, KlaudiaČ, Iveta P, KatarínaV, Štefan F. Effect of dietary Salvia officinalis essential oil and sodium selenite supplementation on antioxidative status and blood phagocytic activity in broiler chickens. ACTA VET. BRNO. 2013;82:043-048. | ||
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سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب