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Improvement of Hypericin and Hyperforin Production Using Zinc and Iron Nano-oxides as Elicitors in Cell Suspension Culture of St John's wort (Hypericum perforatum L.) | ||
| Journal of Medicinal plants and By-product | ||
| مقاله 10، دوره 2، شماره 2، آذر 2013، صفحه 177-184 اصل مقاله (407.69 K) | ||
| شناسه دیجیتال (DOI): 10.22092/jmpb.2013.108592 | ||
| نویسندگان | ||
| Ebrahim Sharafi1، 2؛ Seyyed Mojtaba Khayam Nekoei3؛ Mohamad Hossein Fotokian2؛ Dariush Davoodi4؛ Hossein Hadavand Mirzaei1؛ Tahereh Hasanloo* 1 | ||
| 1Department of Molecular Physiology, Agricultural Biotechnology Research Institute of Iran, Mahdasht Road, P. O. Box 31535-1897, Karaj, Iran | ||
| 2Department of Agricultural Biotechnology, Shahed University, Tehran, Iran | ||
| 3Department of Microbial Biotechnology, Agricultural Biotechnology Research Institute of Iran, Mahdasht Road, P. O. Box 31535-1897, Karaj, Iran | ||
| 4Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran, Mahdasht Road, P. O. Box 31535-1897, Karaj, Iran | ||
| چکیده | ||
| Zinc and iron nano-oxides (100 ppb) were promoted the hypericin and hyperforin production in Hypericum perforatum cell suspension culture. High performance liquid chromatography method was used for detectection and identification of hypericin and hyperforin in H. perfuratum cell suspension cultures elicited with different concentrations of zinc and iron nano-oxide (0, 50, 100 and 150 ppb) after 72 h. In the cultures stimulated by zinc nano-oxide, the hypericin and hyperforin production reached to the maximum (7.87 and 217.45 µg/g DW, respectively), which were 3 and 13-fold higher than the control. The amount of hypericin and hyperforin was increased from 2.07 and 16.27 µg/g DW to 11.18 and 195.62 µg/g DW in iron nano-oxide treated cultures. The cell cultures treated with zinc and iron nano-oxides showed increased hyperforin production as compared to the hypericin production. These observations suggested that nano-particles can be appropriate candidates for elicitation studies of in vitro secondary metabolites production. | ||
| کلیدواژه‌ها | ||
| Cell suspension؛ Hypericum perfuratum؛ Hypericin؛ Hyperforin؛ Nano-particles | ||
| مراجع | ||
|
1. Deltito J, Beyer D. The scientific, quasi-scientific and popular literature on the use of St. John's Wort in the treatment of depression. Affect Disorders. 1998;51:245-251.
2. Dias ACP, Tomas-Barberan FA, Fernandes-Ferreira M, Ferreas F. Unusual flavonoids produced by callus cultures of Hypericum perforatum. Phytochem. 1998;48:1156-1168.
3. Alan L, Miller ND. St. John's Wort (Hypericum perforatum): clinical effects on depression and other condition. Alternative Medicine Review.1998;3:18-26
4. Agostinis P, Vantieghem A, Merlevede W, Peter AM. Hypericin in cancer treatment: More light on the way. The Intrt J Biochem Cell Biol. 2009;34:221-241.
5. Barnes J, Anderson LA, Phillipson JD. St John's Wort (Hypericum perforatum L.): review of its chemistry, pharmacology and clinical properties. J Pharm Pharmacol. 2001;53:583-600.
6. Ishiguro K, Nagareya N, Fukomoto H. A phloroglucinol derivative from cell suspension cultures of Hypericum perforatum L. Phytochem. 1998;47:347-369.
7. Silva BA, Ferreres F, Malva JO, Dias ACP. Phytochemical and antioxidant characterization of Hypericum perforatum alcoholic extracts. Food Chem. 2005;90:157-167.
8. Simon JC. Inhibition of tumor cell growth by hyperforin, a novel anticancer drug from St. John's Wort that acts by induction of apoptosis. Oncogene. 2002;21:1242-1250.
9. Towers GHN, Hudson JB. Light-mediated biological activities of natural products from plant and fungi. Current Organ Chem.1998;1:396-414.
10. Dörnenberg H, Knorr D. Challenges and opportunities for metabolite production from plant cell and tissue cultures. Food Technol. 1997;51:47-54.
11. Van Etten HD, Mansfield JW, Bailey JA, Farmer EE. Two classes of plant antibiotics phytoalexins versus "phytoantici-pins". Plant Cell. 1994;6:1191-1192.
12. Walker TS, Bais HP, Vivanco JM. Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John's wort). Phytochem. 2002;60:289-293.
13. Çirak C, Aksoy HM, Ayan AK, Saglam B, Kevseroglu K. Enhanced hypericin production in Hypericum perforatum and Hypericum pruinatum in Response to Inoculation with Two Fungal Pathogens. Plant Prot Sci. 2005;3:109- 114.
14. Liu NX, Zhang XQ, Sun JS. Effects of cytokinin and elicitors on the production of hypericins and hyperforin metabolites in Hypericum perforatum and Hypericum sampsonii. Plant Growth Regul. 2007;53:207-214.
15. Hollister P, Weener JW, Roman Vas C, Harper T. Nanoparticles technology white papers. 2003;3:1-11.
16. Gonzalez-melendi P, Fernandez-pacheco R, Coronado MJ, Corredor E, Testillano PS, Risuno MC, Marquina C, Ibarra MR, Rubiales D, Perez-de-luque A. Nanoparticles as smart treatment-delivery systems in plant: assessment of different techniques of microscopy for their visualization in plant tissues. Annal Botan. 2008;101:187- 195.
17. Laurent S, Forge D, Port M, Roch A, Robic C, Vander EL, Muller R. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical Characterizations, and Biological Applications. Chemical Reviews. 2008;108:2064-110.
18. Teja A, Koh P. Synthesis, properties, and applications of magnetic iron oxide nanoparticles. Progress in Crystal Growth and Characterization of Materials.2009;55:22-28.
19. Hernandezbattez A, Gonzalez R, Viesca J, Fernandez J, Diazfernandez J, MacHado A, Chou R, Riba J. Cuo, zro2 and zno nanoparticles as antiwear additive in oil lubricants. Wear. 2008;265:422-427.
20. Liedekerke MD. Zinc Oxide (Zinc White): Pigments, Inorganic, 1" in Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH Weinheim. 2006; 22: 111- 116.
21. Baruah S, Dutta J. Hydrothermal growth of ZnO nanostructures. Science and Technology of Advanced Materials. 2009;10: 013001.
22. Miao L, Ieda Y, Tanemura S, Cao YG, Tanemura M, Hayashi Y, Toh S, Kaneko KSynthesis, microstructure and photoluminescence of well-aligned ZnO nanorods on Si substrate. Science and Technology of Advanced Materials. 2007;8:443.
23. Nair R, Varghese SH, Nair GB, Maekawa T, Yoshida Y, Kumar DS. Nanoparticulate material delivery to plants. Plant Sci. 2010; 179: 154-163.
24. Brayner R, Ferrari R, Brivois N, Djediat S, Benedetti MF, Fievet F. Toxicological impact studies based on Eschericha coli bacteria in ultrafine Zno nanoparticles colloidal medium. Nano Letter. 2006;6:866-870.
25. Lee MW, An YJ, Kweon HS. Toxicity and bioavailability of copper nanoparticles to terrestrial plants Phaseolus radiatus (Mung bean) and Triticum aestivum (Wheat); plant agar test for water-insoluble nanoparticles. Environ Sci Technol. 2008;27:1915-1921.
26. Lin D, Xing B. Root uptake and phytotoxicity of Zno noparticles. Environ Sci Technol. 2008; 42: 5580-5582.
27. Sondi L, Salopek B. Silver nanoparticles as antimicrobial agent: a case study on E. coli as model Gram-negative bacteria. J Colloid Interface Sci. 2004;275:177-182.
28. Murashige T, Skoog F. A revised medium for rapid growth and bioassays with tabacoo tissue cultures. Plant Physiol. 1967;15:437-497.
29. Gadzovska S, Maury S, Delaunay A, Spasenoski M, Joseph J, Hage`ge D. Jasmonic acid elicitation of Hypericum perforatum L. cell suspensions and effects on the production of phenylpropanoids and naphtodianthrones. Plant Cell, Tissue and Organ Culture. 2007;89:1-13.
30. Liu X, Zhang X, Zhang S, Sun J. Regulation of metabolite production by precursors and elicitors in liquid cultures of Hypericum perforatum. plant cell tissue organ culture. 2007;91:1-7.
31. Menke F, Champion A, Kijne J, Memelink J. A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate and elicitorinducible AP2-domain transcription factor, ORCA2. European Molecul Biol Organization. 2009;18:4455-4463.
32. Yang L, Watts DJ. Particle surface characteristics may play an important role in hytotoxicity of alumina nanoparticles. Toxicolology Letters. 2005;158:122-123. | ||
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