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مقایسه اثر عصاره الکلی دارچین سیلان با روغن دانه کتان در التیام زخم‌های جلدی رت | ||
| تحقیقات گیاهان دارویی و معطر ایران | ||
| مقاله 9، دوره 31، شماره 6 - شماره پیاپی 74، بهمن 1394، صفحه 1005-1012 اصل مقاله (264.29 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22092/ijmapr.2016.105889 | ||
| نویسندگان | ||
| سعید حصارکی1؛ محمدرضا فرهپور2؛ بهروز یحیایی3 | ||
| 1استادیار، گروه پاتوبیولوژی، دانشگاه آزاد اسلامی، واحد علوم و تحقیقات تهران، ایران | ||
| 2استادیار، گروه علوم درمانگاهی، دانشگاه آزاد اسلامی، واحد ارومیه، ایران | ||
| 3استادیار، گروه پزشکی، دانشگاه آزاد اسلامی، واحد شاهرود، ایران | ||
| چکیده | ||
| زخم رویدادی اجتناب‌ناپذیر در زندگی بوده که به علت عفونت میکروبی و یا آسیب فیزیکی یا شیمیایی بوجود می‌آید. مطالعه حاضر به‌منظور مقایسه اثر دارچین سیلان در التیام زخم‌های القا شده در رت با دانه کتان انجام شده است. تعداد سی و دو رت به چهار گروه هشت‌تایی تقسیم شدند. روند التیام زخم گروه‌های مربوط به عصاره 3% دارچین سیلان و غلظت 3% روغن دانه کتان در روزهای 3، 7، 14 و 21 مورد ارزیابی قرار گرفتند. همچنین یک گروه به‌عنوان شاهد هیچ دارویی دریافت نکرده و یک گروه به‌عنوان مرجع استاندارد، پماد وازلین اوسرین را دریافت کردند. نتایج نشان داد که عصاره دارچین و روغن بذر کتان در سرعت بخشیدن به روند التیام زخم‌ها مؤثر بوده و به‌طور خاص سرعت پیدایش اپیتلیوم در گروه تحت درمان را نسبت به گروه‌های دیگر افزایش داد، به‌طوری که اندازه محوطه زخم در گروه دارچین و در روز 21 برابر 04/0±6/2، در گروه دانه کتان 05/0±72/3، در گروه دارونما 09/0±01/5 و در گروه شاهد 07/0±3/5 بود. ارزیابی مقایسه‌ای این مطالعه نشان داد که عصاره دارچین سیلان در تسریع جمع شدن زخم از دانه کتان مؤثرتر بود. | ||
| کلیدواژه‌ها | ||
| التیام زخم؛ دارچین سیلان؛ روغن دانه کتان؛ تولید اپیتلیوم | ||
| عنوان مقاله [English] | ||
| Effects of Ceylon cinnamon ethanolic extract and flaxseed oil on cutaneous wounds healing in rat | ||
| نویسندگان [English] | ||
| S. Hesaraki1؛ M.R. Farahpour2؛ B. Yahyaei3 | ||
| 1Department of Pathobiology, Islamic Azad University, Science and Research Branch, Tehran, Iran | ||
| 2Department of Clinical Sciences, Islamic Azad University, Urmia Branch, Urmia, Iran | ||
| 3Department of Medical Sciences, Islamic Azad University, Shahrood Branch, Shahrood, Iran | ||
| چکیده [English] | ||
| Wound is an inevitable event in life, occurring due to microbial infection or physical or chemical damage. The present study was conducted in order to compare the effect of Ceylon cinnamon extract and flaxseed oil on the healing of wounds induced in rat. Thirty-two rats were divided into four groups. The wound healing process was evaluated for groups related to Ceylon cinnamon ethanolic extract (3%) and flaxseed oil at a concentration of 3% on days 3, 7, 14 and 21. In addition, one group received no treatment as control, and one group received the vaseline eucerin ointment as reference standard. The results showed that Ceylon cinnamon extract and flaxseedoil were effective in accelerating the wounds healing process and, in particular, increased epithelization rate in the treatment groups compared to the other groups, so that the size of the wound area in the Ceylon cinnamon group, flaxseedoil group, placebo group and the control group on day 21 were calculated to be 2.6±0.4, 3.72±0.05, 5.01±0.09 and 5.3±0.07, respectively. Comparative evaluation of this study showed that Ceylon cinnamon was more effective in accelerating the closure of wound as compared with flaxseed oil. | ||
| کلیدواژه‌ها [English] | ||
| WOUND HEALING, Ceylon cinnamon, flaxseed oil, epithelization | ||
| مراجع | ||
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